{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bennett G"],"funding":["NIGMS NIH HHS"],"pagination":["38-45"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4425604"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30"],"pubmed_abstract":["The DNA damage response to double-strand breaks (DSBs) is critical for cellular viability. Recent work has shown that a host of chromatin regulators are recruited to a DSB, and that they are important for the DNA damage response. However, the functional relationships between different chromatin regulators at DSBs remain unclear. Here we describe a conserved functional interaction among the chromatin remodeling enzyme, SWI/SNF, the NuA4 and Gcn5 histone acetyltransferases, and phosphorylation of histone H2A.X (?H2AX). Specifically, we find that the NuA4 and Gcn5 enzymes are both required for the robust recruitment of SWI/SNF to a DSB, which in turn promotes the phosphorylation of H2A.X."],"journal":["DNA repair"],"pubmed_title":["SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases."],"pmcid":["PMC4425604"],"funding_grant_id":["R01 GM054096","GM54096"],"pubmed_authors":["Bennett G","Peterson CL"],"additional_accession":[]},"is_claimable":false,"name":"SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases.","description":"The DNA damage response to double-strand breaks (DSBs) is critical for cellular viability. Recent work has shown that a host of chromatin regulators are recruited to a DSB, and that they are important for the DNA damage response. However, the functional relationships between different chromatin regulators at DSBs remain unclear. Here we describe a conserved functional interaction among the chromatin remodeling enzyme, SWI/SNF, the NuA4 and Gcn5 histone acetyltransferases, and phosphorylation of histone H2A.X (?H2AX). Specifically, we find that the NuA4 and Gcn5 enzymes are both required for the robust recruitment of SWI/SNF to a DSB, which in turn promotes the phosphorylation of H2A.X.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jun","modification":"2020-10-29T11:41:49Z","creation":"2019-03-27T01:51:17Z"},"accession":"S-EPMC4425604","cross_references":{"pubmed":["25869823"],"doi":["10.1016/j.dnarep.2015.03.006"]}}