{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bennett JL"],"funding":["NEI NIH HHS","NINDS NIH HHS"],"pagination":["678-88"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4425816"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(6)"],"pubmed_abstract":["Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Fu"],"journal":["Multiple sclerosis (Houndmills, Basingstoke, England)"],"pubmed_title":["Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography."],"pmcid":["PMC4425816"],"funding_grant_id":["K08 NS078555","K23 NS069806","R01 EY022936"],"pubmed_authors":["de Seze J","Green A","Kim HJ","GJCF-ICC&BR","Banwell B","Chan KH","Zimmermann H","Saiz A","Fujihara K","Lana-Peixoto M","Villoslada P","Bennett JL","Schippling S","Greenberg B","Palace J","Asgari N","Wuerfel J","Tenembaum S","Waldman A","Levy M","Sato DK","Paul F"],"additional_accession":[]},"is_claimable":false,"name":"Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography.","description":"Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Fu","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 May","modification":"2025-04-19T02:55:03.771Z","creation":"2019-03-27T01:51:18Z"},"accession":"S-EPMC4425816","cross_references":{"pubmed":["25662342"],"doi":["10.1177/1352458514567216"]}}