{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["211(10)"],"submitter":["Eller MA"],"funding":["Intramural NIH HHS"],"pubmed_abstract":["<h4>Background</h4>Untreated human immunodeficiency virus type 1 (HIV) infection is associated with persistent immune activation, which is an independent driver of disease progression in European and United States cohorts. In Uganda, HIV-1 subtypes A and D and recombinant AD viruses predominate and exhibit differential rates of disease progression.<h4>Methods</h4>HIV-1 seroconverters (n = 156) from rural Uganda were evaluated to assess the effects of T-cell activation, viral load, and viral subtype on disease progression during clinical follow-up.<h4>Results</h4>The frequency of activated T cells was increased in HIV-1-infected Ugandans, compared with community matched uninfected individuals, but did not differ significantly between viral subtypes. Higher HIV-1 load, subtype D, older age, "],"journal":["The Journal of infectious diseases"],"pagination":["1574-84"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4425824"],"repository":["biostudies-literature"],"pubmed_title":["HIV Type 1 Disease Progression to AIDS and Death in a Rural Ugandan Cohort Is Primarily Dependent on Viral Load Despite Variable Subtype and T-Cell Immune Activation Levels."],"pmcid":["PMC4425824"],"pubmed_authors":["Opollo MS","Eller LA","Gray RH","Eller MA","Milazzo M","Liu M","Sewankambo NK","Kiwanuka N","Serwadda D","Laeyendecker O","Wabwire-Mangen F","Sandberg JK","Quinn TC","Kityo C","Kayiwa J","Wawer MJ","Redd AD","Robb ML","Michael NL"],"additional_accession":[]},"is_claimable":false,"name":"HIV Type 1 Disease Progression to AIDS and Death in a Rural Ugandan Cohort Is Primarily Dependent on Viral Load Despite Variable Subtype and T-Cell Immune Activation Levels.","description":"<h4>Background</h4>Untreated human immunodeficiency virus type 1 (HIV) infection is associated with persistent immune activation, which is an independent driver of disease progression in European and United States cohorts. In Uganda, HIV-1 subtypes A and D and recombinant AD viruses predominate and exhibit differential rates of disease progression.<h4>Methods</h4>HIV-1 seroconverters (n = 156) from rural Uganda were evaluated to assess the effects of T-cell activation, viral load, and viral subtype on disease progression during clinical follow-up.<h4>Results</h4>The frequency of activated T cells was increased in HIV-1-infected Ugandans, compared with community matched uninfected individuals, but did not differ significantly between viral subtypes. Higher HIV-1 load, subtype D, older age, ","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 May","modification":"2025-04-19T02:55:09.934Z","creation":"2019-03-27T01:51:18Z"},"accession":"S-EPMC4425824","cross_references":{"pubmed":["25404522"],"doi":["10.1093/infdis/jiu646"]}}