biostudies-literatureUnknown211(10)Eller MAIntramural NIH HHS<h4>Background</h4>Untreated human immunodeficiency virus type 1 (HIV) infection is associated with persistent immune activation, which is an independent driver of disease progression in European and United States cohorts. In Uganda, HIV-1 subtypes A and D and recombinant AD viruses predominate and exhibit differential rates of disease progression.<h4>Methods</h4>HIV-1 seroconverters (n = 156) from rural Uganda were evaluated to assess the effects of T-cell activation, viral load, and viral subtype on disease progression during clinical follow-up.<h4>Results</h4>The frequency of activated T cells was increased in HIV-1-infected Ugandans, compared with community matched uninfected individuals, but did not differ significantly between viral subtypes. Higher HIV-1 load, subtype D, older age, The Journal of infectious diseases1574-84https://www.ebi.ac.uk/biostudies/studies/S-EPMC4425824biostudies-literatureHIV Type 1 Disease Progression to AIDS and Death in a Rural Ugandan Cohort Is Primarily Dependent on Viral Load Despite Variable Subtype and T-Cell Immune Activation Levels.PMC4425824Opollo MSEller LAGray RHEller MAMilazzo MLiu MSewankambo NKKiwanuka NSerwadda DLaeyendecker OWabwire-Mangen FSandberg JKQuinn TCKityo CKayiwa JWawer MJRedd ADRobb MLMichael NLfalseHIV Type 1 Disease Progression to AIDS and Death in a Rural Ugandan Cohort Is Primarily Dependent on Viral Load Despite Variable Subtype and T-Cell Immune Activation Levels.<h4>Background</h4>Untreated human immunodeficiency virus type 1 (HIV) infection is associated with persistent immune activation, which is an independent driver of disease progression in European and United States cohorts. In Uganda, HIV-1 subtypes A and D and recombinant AD viruses predominate and exhibit differential rates of disease progression.<h4>Methods</h4>HIV-1 seroconverters (n = 156) from rural Uganda were evaluated to assess the effects of T-cell activation, viral load, and viral subtype on disease progression during clinical follow-up.<h4>Results</h4>The frequency of activated T cells was increased in HIV-1-infected Ugandans, compared with community matched uninfected individuals, but did not differ significantly between viral subtypes. Higher HIV-1 load, subtype D, older age, 2015-01-01T00:00:00Z2015 May2025-04-19T02:55:09.934Z2019-03-27T01:51:18ZS-EPMC44258242540452210.1093/infdis/jiu646