{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["SIGMA Type 2 Diabetes Consortium"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS","NCI NIH HHS"],"pagination":["2305-14"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4425850"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["311(22)"],"pubmed_abstract":["<h4>Importance</h4>Latino populations have one of the highest prevalences of type 2 diabetes worldwide.<h4>Objectives</h4>To investigate the association between rare protein-coding genetic variants and prevalence of type 2 diabetes in a large Latino population and to explore potential molecular and physiological mechanisms for the observed relationships.<h4>Design, setting, and participants</h4>Whole-exome sequencing was performed on DNA samples from 3756 Mexican and US Latino individuals (1794 with type 2 diabetes and 1962 without diabetes) recruited from 1993 to 2013. One variant was further tested for allele frequency and association with type 2 diabetes in large multiethnic data sets of 14,276 participants and characterized in experimental assays.<h4>Main outcome and measures</h4>Preva"],"journal":["JAMA"],"pubmed_title":["Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population."],"pmcid":["PMC4425850"],"funding_grant_id":["R35 CA053890","R01 CA080205","U01 DK062370","R01 DK047482","R01 CA80205","R01DK053889","R01 DK053889","R01 CA144034","R01 DK042273","CA054281","P30 DK020572","P01 HL045522","U01 CA063464","R01 DK098032","R01 CA055069","P01HL045522","CA063464","R37 CA054281","R01HL24799","U01DK085501","U01 CA164973","R01 DK057295","U01 DK057295","R35CA53890","U01 DK085501","R01 DK033665","U01DK085526","U01 DK085526","R01 CA063464","R01 CA054281","CA164973","R01DK047482","UM1 CA164973"],"pubmed_authors":["Florez JC","Burtt NP","Estrada K","Lehman DM","Najmi LA","Hanis CL","Cortes ML","Le Marchand L","Arellano-Campos O","Gonzalez-Villalpando ME","Mendoza-Caamal E","Orozco L","Rodriguez-Guillen R","Gabriel S","Abboud HE","Garcia-Ortiz H","MacArthur DG","Soberon X","Njolstad PR","Gomez-Vazquez MJ","Bjorkhaug L","Bell GI","Centeno-Cruz F","Huerta-Chagoya A","Islas-Andrade S","Henderson E","Mercader JM","Fontanillas P","Altshuler D","Revilla-Monsalve C","Williams AL","Cordova EJ","Gonzalez-Villalpando C","Fernandez-Lopez JC","Aukrust I","Haiman CA","Fernandez-Lopez A","Riba L","SIGMA Type 2 Diabetes Consortium","Rodriguez-Torres M","Jenkinson CP","Martinez-Hernandez A","Fennell T","Tusie-Luna T","Aguilar-Salinas CA","Walford G","Wilkens LR","Boehnke M","Moreno-Macias H","Jimenez-Morales S","Ordonez-Sanchez ML","Henderson BE","Jacobs SB","Flannick J"],"additional_accession":[]},"is_claimable":false,"name":"Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.","description":"<h4>Importance</h4>Latino populations have one of the highest prevalences of type 2 diabetes worldwide.<h4>Objectives</h4>To investigate the association between rare protein-coding genetic variants and prevalence of type 2 diabetes in a large Latino population and to explore potential molecular and physiological mechanisms for the observed relationships.<h4>Design, setting, and participants</h4>Whole-exome sequencing was performed on DNA samples from 3756 Mexican and US Latino individuals (1794 with type 2 diabetes and 1962 without diabetes) recruited from 1993 to 2013. One variant was further tested for allele frequency and association with type 2 diabetes in large multiethnic data sets of 14,276 participants and characterized in experimental assays.<h4>Main outcome and measures</h4>Preva","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jun","modification":"2026-05-01T18:15:35.386Z","creation":"2019-03-27T01:51:17Z"},"accession":"S-EPMC4425850","cross_references":{"pubmed":["24915262"],"doi":["10.1001/jama.2014.6511"]}}