{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sterpone F"],"funding":["European Research Council"],"pagination":["4871-93"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4426487"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(13)"],"pubmed_abstract":["The OPEP coarse-grained protein model has been applied to a wide range of applications since its first release 15 years ago. The model, which combines energetic and structural accuracy and chemical specificity, allows the study of single protein properties, DNA-RNA complexes, amyloid fibril formation and protein suspensions in a crowded environment. Here we first review the current state of the model and the most exciting applications using advanced conformational sampling methods. We then present the current limitations and a perspective on the ongoing developments."],"journal":["Chemical Society reviews"],"pubmed_title":["The OPEP protein model: from single molecules, amyloid formation, crowding and hydrodynamics to DNA/RNA systems."],"pmcid":["PMC4426487"],"funding_grant_id":["258748"],"pubmed_authors":["St-Pierre JF","Laurin Y","Mousseau N","Chebaro Y","Kalimeri M","Derreumaux P","Cragnolini T","Pasquali S","Tek A","Sterpone F","Tuffery P","Baaden M","Melchionna S","Nguyen PH","Barducci A"],"additional_accession":[]},"is_claimable":false,"name":"The OPEP protein model: from single molecules, amyloid formation, crowding and hydrodynamics to DNA/RNA systems.","description":"The OPEP coarse-grained protein model has been applied to a wide range of applications since its first release 15 years ago. The model, which combines energetic and structural accuracy and chemical specificity, allows the study of single protein properties, DNA-RNA complexes, amyloid fibril formation and protein suspensions in a crowded environment. Here we first review the current state of the model and the most exciting applications using advanced conformational sampling methods. We then present the current limitations and a perspective on the ongoing developments.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jul","modification":"2026-05-02T10:17:22.107Z","creation":"2026-04-07T17:53:05.936Z"},"accession":"S-EPMC4426487","cross_references":{"pubmed":["24759934"],"doi":["10.1039/c4cs00048j"]}}