{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang L"],"funding":["NICHD NIH HHS","NHLBI NIH HHS"],"pagination":["e0126576"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4428707"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(5)"],"pubmed_abstract":["The surfactant protein (SP-A) receptor SP-R210 has been shown to increase phagocytosis of SP-A-bound pathogens and to modulate cytokine secretion by immune cells. SP-A plays an important role in pulmonary immunity by enhancing opsonization and clearance of pathogens and by modulating macrophage inflammatory responses. Alternative splicing of the Myo18A gene results in two isoforms: SP-R210S and SP-R210L, with the latter predominantly expressed in alveolar macrophages. In this study we show that SP-A is required for optimal expression of SP-R210L on alveolar macrophages. Interestingly, pre-treatment with SP-A prepared by different methods either enhances or suppresses responsiveness to LPS, possibly due to differential co-isolation of SP-B or other proteins. We also report that dominant neg"],"journal":["PloS one"],"pubmed_title":["SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation."],"pmcid":["PMC4428707"],"funding_grant_id":["HL068127","HL-34788","K12 HD055882","R01 HL034788","R01 HL068127","R37 HL034788"],"pubmed_authors":["Floros J","Hu S","Yang L","Silveyra P","DiAngelo SL","Halstead ES","Chroneos ZC","Wu YM","Davies ML","Christensen ND","Umstead TM","Carrillo M","McCormack FX"],"additional_accession":[]},"is_claimable":false,"name":"SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation.","description":"The surfactant protein (SP-A) receptor SP-R210 has been shown to increase phagocytosis of SP-A-bound pathogens and to modulate cytokine secretion by immune cells. SP-A plays an important role in pulmonary immunity by enhancing opsonization and clearance of pathogens and by modulating macrophage inflammatory responses. Alternative splicing of the Myo18A gene results in two isoforms: SP-R210S and SP-R210L, with the latter predominantly expressed in alveolar macrophages. In this study we show that SP-A is required for optimal expression of SP-R210L on alveolar macrophages. Interestingly, pre-treatment with SP-A prepared by different methods either enhances or suppresses responsiveness to LPS, possibly due to differential co-isolation of SP-B or other proteins. We also report that dominant neg","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2025-04-22T07:09:00.803Z","creation":"2019-03-26T23:32:41Z"},"accession":"S-EPMC4428707","cross_references":{"pubmed":["25965346"],"doi":["10.1371/journal.pone.0126576"]}}