{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["128(9)"],"submitter":["Mathuranyanon R"],"pubmed_abstract":["Accumulation of unfolded proteins in the endoplasmic reticulum (ER) accompanies ER stress and causes the type-I transmembrane protein Ire1 (also known as ERN1) to trigger the unfolded protein response (UPR). When dimerized, the core stress-sensing region (CSSR) of Ire1 directly captures unfolded proteins and forms a high-order oligomer, leading to clustering and activation of Ire1. The CSSR is N-terminally flanked by an intrinsically disordered subdomain, which we previously named Subregion I, in Saccharomyces cerevisiae Ire1. In this study, we describe tight repression of Ire1 activity by Subregion I under conditions of no or weak stress. Weak hyperactivation of an Ire1 mutant lacking Subregion I slightly retarded growth of yeast cells cultured under unstressed conditions. Fungal Ire1 ort"],"journal":["Journal of cell science"],"pagination":["1762-72"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4432228"],"repository":["biostudies-literature"],"pubmed_title":["Tight regulation of the unfolded protein sensor Ire1 by its intramolecularly antagonizing subdomain."],"pmcid":["PMC4432228"],"pubmed_authors":["Tsukamoto T","Takeuchi A","Mathuranyanon R","Ishiwata-Kimata Y","Kohno K","Kimata Y","Tsuchiya Y"],"additional_accession":[]},"is_claimable":false,"name":"Tight regulation of the unfolded protein sensor Ire1 by its intramolecularly antagonizing subdomain.","description":"Accumulation of unfolded proteins in the endoplasmic reticulum (ER) accompanies ER stress and causes the type-I transmembrane protein Ire1 (also known as ERN1) to trigger the unfolded protein response (UPR). When dimerized, the core stress-sensing region (CSSR) of Ire1 directly captures unfolded proteins and forms a high-order oligomer, leading to clustering and activation of Ire1. The CSSR is N-terminally flanked by an intrinsically disordered subdomain, which we previously named Subregion I, in Saccharomyces cerevisiae Ire1. In this study, we describe tight repression of Ire1 activity by Subregion I under conditions of no or weak stress. Weak hyperactivation of an Ire1 mutant lacking Subregion I slightly retarded growth of yeast cells cultured under unstressed conditions. Fungal Ire1 ort","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 May","modification":"2025-05-29T19:12:50.044Z","creation":"2019-03-27T01:51:38Z"},"accession":"S-EPMC4432228","cross_references":{"pubmed":["25770101"],"doi":["10.1242/jcs.164111"]}}