biostudies-literatureTridente ANational Institute for Health Research (NIHR)210https://www.ebi.ac.uk/biostudies/studies/S-EPMC4432819biostudies-literatureUnknown19<h4>Introduction</h4>Patients admitted to intensive care following surgery for faecal peritonitis present particular challenges in terms of clinical management and risk assessment. Collaborating surgical and intensive care teams need shared perspectives on prognosis. We aimed to determine the relationship between dynamic assessment of trends in selected variables and outcomes.<h4>Methods</h4>We analysed trends in physiological and laboratory variables during the first week of intensive care unit (ICU) stay in 977 patients at 102 centres across 16 European countries. The primary outcome was 6-month mortality. Secondary endpoints were ICU, hospital and 28-day mortality. For each trend, Cox proportional hazards (PH) regression analyses, adjusted for age and sex, were performed for each endpoiCritical care (London, England)Association between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort.PMC4432819NIHR/CS/009/007Kowalski WClay SRoughton SBentley AMillward KAsfar PDorado FFWheatley NGenOSept InvestigatorsSatinsky ITaylor JLowes SWujtewicz MBiston PDrobnik LParsons PPahary SThornton JOkros IGordon ACVan Der Hoven BAinsworth MHutcheon EHall SMargarit-Ribas AFletcher SHall PGibson CNovak IMowattWheatley EBloos FEngland JNovak HMountford LBobek IWilliams SFlitchett VElliot SBurfield SKanski ACotogni PJones CNierhaus AVKarpel EDonnelly MWong KWaterhouse NGocher DGupta RGhosh AMartin MCRanieri MYebenes JCGriffin-Teal NMills GHMacchiovello LBlunt MCarrasco NTufano RLabarta LLev ALarsenArcher EBowrey SDowns DThompson JZiajka AMills GMcLees EBares DPambakian SChiche JDWatt PBedos JPMitchell-Inwang CKusza KTurani FOram MSiemiatkowski AGuleri ACody CTennant HMarek OSarapuu SBakarr Karim AJastrzebski JHyun Ryu JWilde JPirie CSirvent JMHugill KGasparovic VKrassler JDrage SMills NBercades GBellingan GPesenti ADarvas KWeiss YHayes MIsgro FGil Cebrian JKrawczyk LRaymode PRabbat AEvrenoglou DRyan TMahecic TMannova JAtkinson JAddison JMorris SOrtiz-Ruiz De Gordoa LMawer DKoscielniak WMikstacki ADlamini MGarrard CRello JWeiss MChallis KWhitehead IArmagandis ANyabadza SLauterbach MGoodridge VJevdjic JStuber FPerez-Fernandez XLSorrell JWatters MMallick ASramek VJacques NGrundling MDe Gaudio ARCollins JSanchez PWilson RSimpson EKrupe IArmaganidis AWilson NHyvernat HGomez-Martinez ENestorowic ALees SCollin VMusaad SJaschinski UWaddington NHutton PBland MJohnston ALisboa THewlett JRyan CSvoren EBaldwin JPanko MLaha SSole-Violan JHazelzet JSangiorgi GRosbergen MThomas GDaglish JGaszynski WMoreno Cuesta JThomson EGlister GGibbs CCocker JHolloway PAPizov RGaszynski RFindlay GGonzalez-Moreno JNillson AMayell KAndrews SGarfield MJCalderwood JJozef BSpapen HSmolen SGattinoni LTimmins ACambra LBaudouin SKubler AHudson PZykova ISierra RlRagaller MBullock LCastello MBMotherway CMurdoch SMappleback SHigham CDugernier TThunder OLaterre PFLaffey JSirgo GKapila ADamas PBailie RHiggins DDurcan JClarke GMTridente ASchroder SFarras-Arraya RSurbatovic MWatson DJefferies FPelaia PProwse HMaciejewski DVidarte-Ortiz MAVojtech SBreen DBion JPesian SJamieson VKrige AMikaszweska-Sokolewicz MKuper MWebster NGrgic MDiaz EUnderwood CConforto FSwan KVenn RWard GMisset BCalton ERich NMargalef JVenkatesh PValverde-Conde ATempleton MHarrison DWalden ALivigni SRogers SDoherty NBonner SWilliamson KNagle JFernandez JLHotchkiss KSmith ABoluda SPurdy ASmith ISherrard Smith LColling KSmith NHinds CCapuzzo MPutensen CDiehl JLBilotta FGordon AfalseAssociation between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort.<h4>Introduction</h4>Patients admitted to intensive care following surgery for faecal peritonitis present particular challenges in terms of clinical management and risk assessment. Collaborating surgical and intensive care teams need shared perspectives on prognosis. We aimed to determine the relationship between dynamic assessment of trends in selected variables and outcomes.<h4>Methods</h4>We analysed trends in physiological and laboratory variables during the first week of intensive care unit (ICU) stay in 977 patients at 102 centres across 16 European countries. The primary outcome was 6-month mortality. Secondary endpoints were ICU, hospital and 28-day mortality. For each trend, Cox proportional hazards (PH) regression analyses, adjusted for age and sex, were performed for each endpoi2015-01-01T00:00:00Z2015 May2026-05-01T14:42:20.653Z2019-03-27T01:51:41ZS-EPMC44328192593938010.1186/s13054-015-0931-8