{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5"],"submitter":["Vaidyanathan R"],"pubmed_abstract":["Microfluidic flow based multiplexed devices have gained significant promise in detecting biomarkers in complex biological samples. However, to fully exploit their use in bioanalysis, issues such as (i) low sensitivity and (ii) high levels of nonspecific adsorption of non-target species have to be overcome. Herein, we describe a new multiplexed device for the sensitive detection of multiple protein biomarkers in serum by using an alternating current (ac) electrohydrodynamics (ac-EHD) induced surface shear forces based phenomenon referred to as nanoshearing. The tunable nature (via manipulation of ac field) of these nanoshearing forces can alter the capture performance of the device (e.g., improved fluid transport enhances number of sensor-target collisions). This can also selectively displa"],"journal":["Scientific reports"],"pagination":["9756"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4432869"],"repository":["biostudies-literature"],"pubmed_title":["A multiplexed device based on tunable nanoshearing for specific detection of multiple protein biomarkers in serum."],"pmcid":["PMC4432869"],"pubmed_authors":["Shiddiky MJ","Vaidyanathan R","Trau M","Rauf S","van Leeuwen LM"],"additional_accession":[]},"is_claimable":false,"name":"A multiplexed device based on tunable nanoshearing for specific detection of multiple protein biomarkers in serum.","description":"Microfluidic flow based multiplexed devices have gained significant promise in detecting biomarkers in complex biological samples. However, to fully exploit their use in bioanalysis, issues such as (i) low sensitivity and (ii) high levels of nonspecific adsorption of non-target species have to be overcome. Herein, we describe a new multiplexed device for the sensitive detection of multiple protein biomarkers in serum by using an alternating current (ac) electrohydrodynamics (ac-EHD) induced surface shear forces based phenomenon referred to as nanoshearing. The tunable nature (via manipulation of ac field) of these nanoshearing forces can alter the capture performance of the device (e.g., improved fluid transport enhances number of sensor-target collisions). This can also selectively displa","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 May","modification":"2025-04-22T10:32:46.634Z","creation":"2019-03-27T01:51:41Z"},"accession":"S-EPMC4432869","cross_references":{"pubmed":["25978807"],"doi":["10.1038/srep09756"]}}