{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Prakash A"],"funding":["Biotechnology and Biological Sciences Research Council"],"pagination":["88"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4432964"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16"],"pubmed_abstract":["<h4>Background</h4>Protein domains display a range of structural diversity, with numerous additions and deletions of secondary structural elements between related domains. We have observed a small number of cases of surprising large-scale deletions of core elements of structural domains. We propose a new concept called domain atrophy, where protein domains lose a significant number of core structural elements.<h4>Results</h4>Here, we implement a new pipeline to systematically identify new cases of domain atrophy across all known protein sequences. The output of this pipeline was carefully checked by hand, which filtered out partial domain instances that were unlikely to represent true domain atrophy due to misannotations or un-annotated sequence fragments. We identify 75 cases of domain at"],"journal":["Genome biology"],"pubmed_title":["Domain atrophy creates rare cases of functional partial protein domains."],"pmcid":["PMC4432964"],"funding_grant_id":["BB/J019240/1"],"pubmed_authors":["Prakash A","Bateman A"],"additional_accession":[]},"is_claimable":false,"name":"Domain atrophy creates rare cases of functional partial protein domains.","description":"<h4>Background</h4>Protein domains display a range of structural diversity, with numerous additions and deletions of secondary structural elements between related domains. We have observed a small number of cases of surprising large-scale deletions of core elements of structural domains. We propose a new concept called domain atrophy, where protein domains lose a significant number of core structural elements.<h4>Results</h4>Here, we implement a new pipeline to systematically identify new cases of domain atrophy across all known protein sequences. The output of this pipeline was carefully checked by hand, which filtered out partial domain instances that were unlikely to represent true domain atrophy due to misannotations or un-annotated sequence fragments. We identify 75 cases of domain at","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Apr","modification":"2026-06-13T03:26:15.619Z","creation":"2019-03-27T01:51:41Z"},"accession":"S-EPMC4432964","cross_references":{"pubmed":["25924720"],"doi":["10.1186/s13059-015-0655-8"]}}