{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5"],"submitter":["Sklirou AD"],"funding":["EU COST"],"pubmed_abstract":["Despite the fact that several natural products (e.g. crude extracts or purified compounds) have been found to activate cell antioxidant responses and/or delay cellular senescence the effect(s) of small peptides on cell viability and/or modulation of protective mechanisms (e.g. the proteostasis network) remain largely elusive. We have thus studied a hexapeptide (Hexapeptide-11) of structure Phe-Val-Ala-Pro-Phe-Pro (FVAPFP) originally isolated from yeast extracts and later synthesized by solid state synthesis to high purity. We show herein that Hexapeptide-11 exhibits no significant toxicity in normal human diploid lung or skin fibroblasts. Exposure of fibroblasts to Hexapeptide-11 promoted dose and time-dependent activation of proteasome, autophagy, chaperones and antioxidant responses rela"],"journal":["Redox biology"],"pagination":["205-215"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4434199"],"repository":["biostudies-literature"],"pubmed_title":["Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts."],"pmcid":["PMC4434199"],"pubmed_authors":["Dominguez M","Sklirou AD","Skaltsounis AL","Papassideri I","Trougakos IP","Ralli M"],"additional_accession":[]},"is_claimable":false,"name":"Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts.","description":"Despite the fact that several natural products (e.g. crude extracts or purified compounds) have been found to activate cell antioxidant responses and/or delay cellular senescence the effect(s) of small peptides on cell viability and/or modulation of protective mechanisms (e.g. the proteostasis network) remain largely elusive. We have thus studied a hexapeptide (Hexapeptide-11) of structure Phe-Val-Ala-Pro-Phe-Pro (FVAPFP) originally isolated from yeast extracts and later synthesized by solid state synthesis to high purity. We show herein that Hexapeptide-11 exhibits no significant toxicity in normal human diploid lung or skin fibroblasts. Exposure of fibroblasts to Hexapeptide-11 promoted dose and time-dependent activation of proteasome, autophagy, chaperones and antioxidant responses rela","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Aug","modification":"2025-06-01T01:01:44.87Z","creation":"2025-06-01T01:01:44.87Z"},"accession":"S-EPMC4434199","cross_references":{"pubmed":["25974626"],"doi":["10.1016/j.redox.2015.04.010"]}}