biostudies-literatureUnknown5Sklirou ADEU COSTDespite the fact that several natural products (e.g. crude extracts or purified compounds) have been found to activate cell antioxidant responses and/or delay cellular senescence the effect(s) of small peptides on cell viability and/or modulation of protective mechanisms (e.g. the proteostasis network) remain largely elusive. We have thus studied a hexapeptide (Hexapeptide-11) of structure Phe-Val-Ala-Pro-Phe-Pro (FVAPFP) originally isolated from yeast extracts and later synthesized by solid state synthesis to high purity. We show herein that Hexapeptide-11 exhibits no significant toxicity in normal human diploid lung or skin fibroblasts. Exposure of fibroblasts to Hexapeptide-11 promoted dose and time-dependent activation of proteasome, autophagy, chaperones and antioxidant responses relaRedox biology205-215https://www.ebi.ac.uk/biostudies/studies/S-EPMC4434199biostudies-literatureHexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts.PMC4434199Dominguez MSklirou ADSkaltsounis ALPapassideri ITrougakos IPRalli MfalseHexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts.Despite the fact that several natural products (e.g. crude extracts or purified compounds) have been found to activate cell antioxidant responses and/or delay cellular senescence the effect(s) of small peptides on cell viability and/or modulation of protective mechanisms (e.g. the proteostasis network) remain largely elusive. We have thus studied a hexapeptide (Hexapeptide-11) of structure Phe-Val-Ala-Pro-Phe-Pro (FVAPFP) originally isolated from yeast extracts and later synthesized by solid state synthesis to high purity. We show herein that Hexapeptide-11 exhibits no significant toxicity in normal human diploid lung or skin fibroblasts. Exposure of fibroblasts to Hexapeptide-11 promoted dose and time-dependent activation of proteasome, autophagy, chaperones and antioxidant responses rela2015-01-01T00:00:00Z2015 Aug2025-06-01T01:01:44.87Z2025-06-01T01:01:44.87ZS-EPMC44341992597462610.1016/j.redox.2015.04.010