biostudies-literatureKairys AENIDDK NIH HHSNIDA NIH HHS131-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC4435781biostudies-literatureUnknown193(1)<h4>Purpose</h4>Interstitial cystitis is a highly prevalent pain condition estimated to affect 3% to 6% of women in the United States. Emerging data suggest there are central neurobiological components to the etiology of this disease. We report the first brain structural imaging findings from the MAPP network with data on more than 300 participants.<h4>Materials and methods</h4>We used voxel based morphometry to determine whether human patients with chronic interstitial cystitis display changes in brain morphology compared to healthy controls. A total of 33 female patients with interstitial cystitis without comorbidities and 33 age and gender matched controls taken from the larger sample underwent structural magnetic resonance imaging at 5 MAPP sites across the United States.<h4>Results</hThe Journal of urologyIncreased brain gray matter in the primary somatosensory cortex is associated with increased pain and mood disturbance in patients with interstitial cystitis/painful bladder syndrome.PMC4435781U01 DK082370DK82370U01 DK082333U01 DK082345U01 DK082342U01 DK082315U01 DK082316U01 DK082325DK82316DK82315DK82325DK82345DK82333DK82344K24 DA029262DK82342Puiu TFarmer MALabus JSHarris REDeutsch GSchmidt-Wilcke TMaravilla KIchesco EClauw DJMartucci KNess TJApkarian AVKairys AEMackey SMayer EAfalseIncreased brain gray matter in the primary somatosensory cortex is associated with increased pain and mood disturbance in patients with interstitial cystitis/painful bladder syndrome.<h4>Purpose</h4>Interstitial cystitis is a highly prevalent pain condition estimated to affect 3% to 6% of women in the United States. Emerging data suggest there are central neurobiological components to the etiology of this disease. We report the first brain structural imaging findings from the MAPP network with data on more than 300 participants.<h4>Materials and methods</h4>We used voxel based morphometry to determine whether human patients with chronic interstitial cystitis display changes in brain morphology compared to healthy controls. A total of 33 female patients with interstitial cystitis without comorbidities and 33 age and gender matched controls taken from the larger sample underwent structural magnetic resonance imaging at 5 MAPP sites across the United States.<h4>Results</h2015-01-01T00:00:00Z2015 Jan2025-04-19T02:53:36.484Z2019-03-27T01:51:48ZS-EPMC44357812513223910.1016/j.juro.2014.08.042