{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang H"],"funding":["Medical Research Council"],"pagination":["993-1002"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4444423"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(9)"],"pubmed_abstract":["<h4>Objective</h4>The HLA-A30-B13-C06 haplotype is reported to be associated with slow disease progression in the HIV-1-infected Northern Han Chinese population, but the mechanism remains unknown.<h4>Design</h4>Gag-specific T-cell responses and gag sequencing were performed in nine B' clade HIV-1-infected HLA-A30-B13-C06-positive slow progressors to understand HLA-associated viral control.<h4>Methods</h4>Interferon-γ ELISPOT assays were performed to determine the Gag-specific T-cell responses and cross-reactivity to variant peptides. Longitudinal HIV-1 gag sequencing was performed at the clonal level.<h4>Results</h4>The overlapping peptides (OLP)-48: RQANFLGKIWPSHKGRPGNF (RL42 Gag434-453); OLP-2: GQLDRWEKIRLRPGGKKKYR (RL42 Gag11-30); OLP-15: VQNLQGQMVHQPISPRTLNA (RL42 Gag135-154) and OLP-1"],"journal":["AIDS (London, England)"],"pubmed_title":["Multilayered HIV-1 gag-specific T-cell responses contribute to slow progression in HLA-A*30-B*13-C*06-positive patients."],"pmcid":["PMC4444423"],"funding_grant_id":["G1001046","MR/L018942/1","G0600520"],"pubmed_authors":["Dong T","Zhao B","An M","Jiang F","Zhang Z","Zhang H","Han X","Shang H","Wang Z","Xu J"],"additional_accession":[]},"is_claimable":false,"name":"Multilayered HIV-1 gag-specific T-cell responses contribute to slow progression in HLA-A*30-B*13-C*06-positive patients.","description":"<h4>Objective</h4>The HLA-A30-B13-C06 haplotype is reported to be associated with slow disease progression in the HIV-1-infected Northern Han Chinese population, but the mechanism remains unknown.<h4>Design</h4>Gag-specific T-cell responses and gag sequencing were performed in nine B' clade HIV-1-infected HLA-A30-B13-C06-positive slow progressors to understand HLA-associated viral control.<h4>Methods</h4>Interferon-γ ELISPOT assays were performed to determine the Gag-specific T-cell responses and cross-reactivity to variant peptides. Longitudinal HIV-1 gag sequencing was performed at the clonal level.<h4>Results</h4>The overlapping peptides (OLP)-48: RQANFLGKIWPSHKGRPGNF (RL42 Gag434-453); OLP-2: GQLDRWEKIRLRPGGKKKYR (RL42 Gag11-30); OLP-15: VQNLQGQMVHQPISPRTLNA (RL42 Gag135-154) and OLP-1","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jun","modification":"2026-05-02T01:28:02.926Z","creation":"2026-04-07T17:30:31.175Z"},"accession":"S-EPMC4444423","cross_references":{"pubmed":["25756195"],"doi":["10.1097/QAD.0000000000000652"]}}