{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Lumen A"],"pubmed_abstract":["A deterministic biologically based dose-response model for the thyroidal system in a near-term pregnant woman and the fetus was recently developed to evaluate quantitatively thyroid hormone perturbations. The current work focuses on conducting a quantitative global sensitivity analysis on this complex model to identify and characterize the sources and contributions of uncertainties in the predicted model output. The workflow and methodologies suitable for computationally expensive models, such as the Morris screening method and Gaussian Emulation processes, were used for the implementation of the global sensitivity analysis. Sensitivity indices, such as main, total and interaction effects, were computed for a screened set of the total thyroidal system descriptive model input parameters. Fu"],"journal":["Frontiers in pharmacology"],"pagination":["107"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4444753"],"repository":["biostudies-literature"],"pubmed_title":["Quantitative global sensitivity analysis of a biologically based dose-response pregnancy model for the thyroid endocrine system."],"pmcid":["PMC4444753"],"pubmed_authors":["McNally K","Fisher JW","Loizou GD","George N","Lumen A"],"additional_accession":[]},"is_claimable":false,"name":"Quantitative global sensitivity analysis of a biologically based dose-response pregnancy model for the thyroid endocrine system.","description":"A deterministic biologically based dose-response model for the thyroidal system in a near-term pregnant woman and the fetus was recently developed to evaluate quantitatively thyroid hormone perturbations. The current work focuses on conducting a quantitative global sensitivity analysis on this complex model to identify and characterize the sources and contributions of uncertainties in the predicted model output. The workflow and methodologies suitable for computationally expensive models, such as the Morris screening method and Gaussian Emulation processes, were used for the implementation of the global sensitivity analysis. Sensitivity indices, such as main, total and interaction effects, were computed for a screened set of the total thyroidal system descriptive model input parameters. Fu","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2025-05-29T19:39:27.077Z","creation":"2025-05-29T19:39:27.077Z"},"accession":"S-EPMC4444753","cross_references":{"pubmed":["26074819"],"doi":["10.3389/fphar.2015.00107"]}}