{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lincoln KM"],"funding":["NIA NIH HHS","PHS HHS","NIGMS NIH HHS"],"pagination":["2712-4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4446701"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["49(26)"],"pubmed_abstract":["Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character."],"journal":["Chemical communications (Cambridge, England)"],"pubmed_title":["A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders."],"pmcid":["PMC4446701"],"funding_grant_id":["P01 AGAG027956","P01 AG027956","T32 AG020494","P01 AG022550","U54 GM104942"],"pubmed_authors":["Lincoln KM","Saunders R","Green KN","Simpkins JW","Julovich DA","Richardson TE","Gonzalez P"],"additional_accession":[]},"is_claimable":false,"name":"A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders.","description":"Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Apr","modification":"2025-04-18T17:32:20.144Z","creation":"2019-03-27T01:52:18Z"},"accession":"S-EPMC4446701","cross_references":{"pubmed":["23437435"],"doi":["10.1039/c2cc36808k"]}}