biostudies-literatureLincoln KMNIA NIH HHSPHS HHSNIGMS NIH HHS2712-4https://www.ebi.ac.uk/biostudies/studies/S-EPMC4446701biostudies-literatureUnknown49(26)Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character.Chemical communications (Cambridge, England)A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders.PMC4446701P01 AGAG027956P01 AG027956T32 AG020494P01 AG022550U54 GM104942Lincoln KMSaunders RGreen KNSimpkins JWJulovich DARichardson TEGonzalez PfalseA potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders.Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character.2013-01-01T00:00:00Z2013 Apr2025-04-18T17:32:20.144Z2019-03-27T01:52:18ZS-EPMC44467012343743510.1039/c2cc36808k