{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu MC"],"funding":["NIDDK NIH HHS","NCRR NIH HHS","NHLBI NIH HHS"],"pagination":["1290-302"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4446876"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(6)"],"pubmed_abstract":["Cardiac dysfunction in CKD is characterized by aberrant cardiac remodeling with hypertrophy and fibrosis. CKD is a state of severe systemic Klotho deficiency, and restoration of Klotho attenuates vascular calcification associated with CKD. We examined the role of Klotho in cardiac remodeling in models of Klotho deficiency-genetic Klotho hypomorphism, high dietary phosphate intake, aging, and CKD. Klotho-deficient mice exhibited cardiac dysfunction and hypertrophy before 12 weeks of age followed by fibrosis. In wild-type mice, the induction of CKD led to severe cardiovascular changes not observed in control mice. Notably, non-CKD mice fed a high-phosphate diet had lower Klotho levels and greatly accelerated cardiac remodeling associated with normal aging compared with those on a normal diet"],"journal":["Journal of the American Society of Nephrology : JASN"],"pubmed_title":["Klotho and phosphate are modulators of pathologic uremic cardiac remodeling."],"pmcid":["PMC4446876"],"funding_grant_id":["R01-DK091392","R01-DK092461","R01 DK081374","R01-HL080144","R01-HL100401","P30DK-07938","R01 DK076116","R01 DK092461","U01 HL100401","R01 DK091392","P30 DK079328","R01-DK07611","P01 DK020543","R01-DK20543","S10 RR022584","R01 HL080144","R01-DK081374","K24 DK093723","R01-HL0980842","P41-RR0022584"],"pubmed_authors":["Shelton J","Shi M","Adams-Huet B","Hu MC","Hill JA","Amaral AP","Moe OW","Paek J","Faul C","Taniguchi M","Cho HJ","Brand M","Hill K","Wolf M","Takahashi M","Kuro-O M"],"additional_accession":[]},"is_claimable":false,"name":"Klotho and phosphate are modulators of pathologic uremic cardiac remodeling.","description":"Cardiac dysfunction in CKD is characterized by aberrant cardiac remodeling with hypertrophy and fibrosis. CKD is a state of severe systemic Klotho deficiency, and restoration of Klotho attenuates vascular calcification associated with CKD. We examined the role of Klotho in cardiac remodeling in models of Klotho deficiency-genetic Klotho hypomorphism, high dietary phosphate intake, aging, and CKD. Klotho-deficient mice exhibited cardiac dysfunction and hypertrophy before 12 weeks of age followed by fibrosis. In wild-type mice, the induction of CKD led to severe cardiovascular changes not observed in control mice. Notably, non-CKD mice fed a high-phosphate diet had lower Klotho levels and greatly accelerated cardiac remodeling associated with normal aging compared with those on a normal diet","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jun","modification":"2025-04-18T17:31:11.362Z","creation":"2019-03-27T01:52:18Z"},"accession":"S-EPMC4446876","cross_references":{"pubmed":["25326585"],"doi":["10.1681/asn.2014050465","10.1681/ASN.2014050465"]}}