{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(2)"],"submitter":["Hong BB"],"pubmed_abstract":["Thrombospondin 1 (THBS1) plays an important role in angiogenesis and tumor progression. The aim of the present study was to investigate the effects of single-nucleotide polymorphisms (rs1478605 and rs3743125) in the untranslated regions of the <i>THBS1</i> gene on the development and progression of gastric cancer. In the case-control study, 275 gastric cancer patients and 275 cancer-free controls were successfully genotyped using polymerase chain reaction-restriction fragment length polymorphism. The data demonstrated that <i>THBS1</i> rs1478605 genotypic distributions significantly differed between the patient and control groups (P=0.005). Carriers of the CC genotype exhibited a decreased risk of developing gastric cancer compared to the carriers of the CT and TT genotypes [adjusted odd r"],"journal":["Biomedical reports"],"pagination":["207-214"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4448071"],"repository":["biostudies-literature"],"pubmed_title":["Association of <i>THBS1</i> rs1478605 T>C in 5'-untranslated regions with the development and progression of gastric cancer."],"pmcid":["PMC4448071"],"pubmed_authors":["Lin JY","Zhu JW","Hong BB","Chen SQ","Qi YL"],"additional_accession":[]},"is_claimable":false,"name":"Association of <i>THBS1</i> rs1478605 T>C in 5'-untranslated regions with the development and progression of gastric cancer.","description":"Thrombospondin 1 (THBS1) plays an important role in angiogenesis and tumor progression. The aim of the present study was to investigate the effects of single-nucleotide polymorphisms (rs1478605 and rs3743125) in the untranslated regions of the <i>THBS1</i> gene on the development and progression of gastric cancer. In the case-control study, 275 gastric cancer patients and 275 cancer-free controls were successfully genotyped using polymerase chain reaction-restriction fragment length polymorphism. The data demonstrated that <i>THBS1</i> rs1478605 genotypic distributions significantly differed between the patient and control groups (P=0.005). Carriers of the CC genotype exhibited a decreased risk of developing gastric cancer compared to the carriers of the CT and TT genotypes [adjusted odd r","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Mar","modification":"2025-04-04T20:10:01.958Z","creation":"2019-03-27T01:52:22Z"},"accession":"S-EPMC4448071","cross_references":{"pubmed":["26075074"],"doi":["10.3892/br.2015.414"]}}