biostudies-literatureUnknown3(2)Hong BBThrombospondin 1 (THBS1) plays an important role in angiogenesis and tumor progression. The aim of the present study was to investigate the effects of single-nucleotide polymorphisms (rs1478605 and rs3743125) in the untranslated regions of the THBS1 gene on the development and progression of gastric cancer. In the case-control study, 275 gastric cancer patients and 275 cancer-free controls were successfully genotyped using polymerase chain reaction-restriction fragment length polymorphism. The data demonstrated that THBS1 rs1478605 genotypic distributions significantly differed between the patient and control groups (P=0.005). Carriers of the CC genotype exhibited a decreased risk of developing gastric cancer compared to the carriers of the CT and TT genotypes [adjusted odd rBiomedical reports207-214https://www.ebi.ac.uk/biostudies/studies/S-EPMC4448071biostudies-literatureAssociation of THBS1 rs1478605 T>C in 5'-untranslated regions with the development and progression of gastric cancer.PMC4448071Lin JYZhu JWHong BBChen SQQi YLfalseAssociation of THBS1 rs1478605 T>C in 5'-untranslated regions with the development and progression of gastric cancer.Thrombospondin 1 (THBS1) plays an important role in angiogenesis and tumor progression. The aim of the present study was to investigate the effects of single-nucleotide polymorphisms (rs1478605 and rs3743125) in the untranslated regions of the THBS1 gene on the development and progression of gastric cancer. In the case-control study, 275 gastric cancer patients and 275 cancer-free controls were successfully genotyped using polymerase chain reaction-restriction fragment length polymorphism. The data demonstrated that THBS1 rs1478605 genotypic distributions significantly differed between the patient and control groups (P=0.005). Carriers of the CC genotype exhibited a decreased risk of developing gastric cancer compared to the carriers of the CT and TT genotypes [adjusted odd r2015-01-01T00:00:00Z2015 Mar2025-04-04T20:10:01.958Z2019-03-27T01:52:22ZS-EPMC44480712607507410.3892/br.2015.414