{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Conradi L"],"funding":["American Heart Association","NIBIB NIH HHS","Deutsche Forschungsgemeinschaft","American Heart Association Postdoctoral Fellowship Award","National Institute of Biomedical Imaging and Bioengineering"],"pagination":["625-31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4449088"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(6)"],"pubmed_abstract":["<h4>Unlabelled</h4>Different tissue-engineering approaches have been developed to induce and promote cardiac regeneration; however, the impact of the immune system and its responses to the various scaffold components of the engineered grafts remains unclear. Fibrin-based engineered heart tissue (EHT) was generated from neonatal Lewis (Lew) rat heart cells and transplanted onto the left ventricular surface of three different rat strains: syngeneic Lew, allogeneic Brown Norway, and immunodeficient Rowett Nude rats. Interferon spot frequency assay results showed similar degrees of systemic immune activation in the syngeneic and allogeneic groups, whereas no systemic immune response was detectable in the immunodeficient group (p < .001 vs. syngeneic and allogeneic). Histological analysis revea"],"journal":["Stem cells translational medicine"],"pubmed_title":["Immunobiology of fibrin-based engineered heart tissue."],"pmcid":["PMC4449088"],"funding_grant_id":["R21 EB012155","E.N.1R21EB012155-01A1","14GRNT18970018","12POST12050363","1R21EB012155-01A1","CO858/1-1","E.N.11IRG5450017","SCHR992/3-1","SCHR992/4-1"],"pubmed_authors":["Eschenhagen T","Hua X","Schrepfer S","Eder A","Hansen A","Conradi L","Reichenspurner H","Schmidt S","Robbins RC","Peters L","Neofytou E","Deuse T","Beygui RE"],"additional_accession":[]},"is_claimable":false,"name":"Immunobiology of fibrin-based engineered heart tissue.","description":"<h4>Unlabelled</h4>Different tissue-engineering approaches have been developed to induce and promote cardiac regeneration; however, the impact of the immune system and its responses to the various scaffold components of the engineered grafts remains unclear. Fibrin-based engineered heart tissue (EHT) was generated from neonatal Lewis (Lew) rat heart cells and transplanted onto the left ventricular surface of three different rat strains: syngeneic Lew, allogeneic Brown Norway, and immunodeficient Rowett Nude rats. Interferon spot frequency assay results showed similar degrees of systemic immune activation in the syngeneic and allogeneic groups, whereas no systemic immune response was detectable in the immunodeficient group (p < .001 vs. syngeneic and allogeneic). Histological analysis revea","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jun","modification":"2025-04-18T16:39:00.927Z","creation":"2019-03-27T01:52:24Z"},"accession":"S-EPMC4449088","cross_references":{"pubmed":["25947338"],"doi":["10.5966/sctm.2013-0202"]}}