{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nazarian A"],"funding":["NIAMS NIH HHS"],"pagination":["2514-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4452435"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(11)"],"pubmed_abstract":["Purpose
Pathologic fractures could be prevented if reliable methods of fracture risk assessment were available. A multicenter prospective study was conducted to identify significant predictors of physicians' treatment plan for skeletal metastasis based on clinical fracture risk assessments and the proposed CT-based Rigidity Analysis (CTRA).Experimental design
Orthopedic oncologists selected a treatment plan for 124 patients with 149 metastatic lesions based on the Mirels method. Then, CTRA was performed, and the results were provided to the physicians, who were asked to reassess their treatment plan. The pre- and post-CTRA treatment plans were compared to identify cases in which the treatment plan was changed based on the CTRA report. Patients were followed for a 4-month pe"],"journal":["Clinical cancer research : an official journal of the American Association for Cancer Research"],"pubmed_title":["Treatment Planning and Fracture Prediction in Patients with Skeletal Metastasis with CT-Based Rigidity Analysis."],"pmcid":["PMC4452435"],"funding_grant_id":["AR055885","T32 AR055885","AR056212","L30 AR056606","R01 AR056212"],"pubmed_authors":["Entezari V","Aboulafia AJ","Snyder BD","Lin PP","Nazarian A","Zurakowski D","Cheung FH","Turcotte R","Anderson ME","Damron TA","Terek RM","Cheng EY","Calderon N","Yaszemski M","Villa-Camacho JC","Hipp JA","Gebhardt MC"],"additional_accession":[]},"is_claimable":false,"name":"Treatment Planning and Fracture Prediction in Patients with Skeletal Metastasis with CT-Based Rigidity Analysis.","description":"Purpose
Pathologic fractures could be prevented if reliable methods of fracture risk assessment were available. A multicenter prospective study was conducted to identify significant predictors of physicians' treatment plan for skeletal metastasis based on clinical fracture risk assessments and the proposed CT-based Rigidity Analysis (CTRA).Experimental design
Orthopedic oncologists selected a treatment plan for 124 patients with 149 metastatic lesions based on the Mirels method. Then, CTRA was performed, and the results were provided to the physicians, who were asked to reassess their treatment plan. The pre- and post-CTRA treatment plans were compared to identify cases in which the treatment plan was changed based on the CTRA report. Patients were followed for a 4-month pe","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jun","modification":"2026-04-30T02:54:29.511Z","creation":"2019-03-27T01:52:36Z"},"accession":"S-EPMC4452435","cross_references":{"pubmed":["25724521"],"doi":["10.1158/1078-0432.CCR-14-2668","10.1158/1078-0432.ccr-14-2668"]}}