biostudies-literatureUnknown3Kannan STransposable elements (TEs) are abundant in mammalian genomes and appear to have contributed to the evolution of their hosts by providing novel regulatory or coding sequences. We analyzed different regions of long intergenic non-coding RNA (lincRNA) genes in human and mouse genomes to systematically assess the potential contribution of TEs to the evolution of the structure and regulation of expression of lincRNA genes. Introns of lincRNA genes contain the highest percentage of TE-derived sequences (TES), followed by exons and then promoter regions although the density of TEs is not significantly different between exons and promoters. Higher frequencies of ancient TEs in promoters and exons compared to introns implies that many lincRNA genes emerged before the split of primates and rodents.Frontiers in bioengineering and biotechnology71https://www.ebi.ac.uk/biostudies/studies/S-EPMC4460805biostudies-literatureTransposable Element Insertions in Long Intergenic Non-Coding RNA Genes.PMC4460805Kannan SChernikova DMilanesi LRogozin IBPoliakov EKoonin EVManagadze DfalseTransposable Element Insertions in Long Intergenic Non-Coding RNA Genes.Transposable elements (TEs) are abundant in mammalian genomes and appear to have contributed to the evolution of their hosts by providing novel regulatory or coding sequences. We analyzed different regions of long intergenic non-coding RNA (lincRNA) genes in human and mouse genomes to systematically assess the potential contribution of TEs to the evolution of the structure and regulation of expression of lincRNA genes. Introns of lincRNA genes contain the highest percentage of TE-derived sequences (TES), followed by exons and then promoter regions although the density of TEs is not significantly different between exons and promoters. Higher frequencies of ancient TEs in promoters and exons compared to introns implies that many lincRNA genes emerged before the split of primates and rodents.2015-01-01T00:00:00Z20152025-04-04T07:29:54.495Z2019-03-27T01:53:08ZS-EPMC44608052610659410.3389/fbioe.2015.00071