{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peixoto LL"],"funding":["NIMH NIH HHS","NHLBI NIH HHS","NINDS NIH HHS","NIGMS NIH HHS","NIH HHS"],"pagination":["S5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4460846"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16 Suppl 5"],"pubmed_abstract":["<h4>Background</h4>A fundamental question in neuroscience is how memories are stored and retrieved in the brain. Long-term memory formation requires transcription, translation and epigenetic processes that control gene expression. Thus, characterizing genome-wide the transcriptional changes that occur after memory acquisition and retrieval is of broad interest and importance. Genome-wide technologies are commonly used to interrogate transcriptional changes in discovery-based approaches. Their ability to increase scientific insight beyond traditional candidate gene approaches, however, is usually hindered by batch effects and other sources of unwanted variation, which are particularly hard to control in the study of brain and behavior.<h4>Results</h4>We examined genome-wide gene expression "],"journal":["BMC genomics"],"pubmed_title":["Memory acquisition and retrieval impact different epigenetic processes that regulate gene expression."],"pmcid":["PMC4460846"],"funding_grant_id":["T32 GM008076","DP2OD007447","T32NS007413","T32 NS007413","DP2 OD007447","K12 GM081259","T32HL007953","R01 MH087463"],"pubmed_authors":["Wimmer ME","Poplawski SG","Peixoto LL","Tudor JC","Abel T","Liu S","Garcia BA","Giese K","Zhang NR","Kenworthy CA","Mizuno K"],"additional_accession":[]},"is_claimable":false,"name":"Memory acquisition and retrieval impact different epigenetic processes that regulate gene expression.","description":"<h4>Background</h4>A fundamental question in neuroscience is how memories are stored and retrieved in the brain. Long-term memory formation requires transcription, translation and epigenetic processes that control gene expression. Thus, characterizing genome-wide the transcriptional changes that occur after memory acquisition and retrieval is of broad interest and importance. Genome-wide technologies are commonly used to interrogate transcriptional changes in discovery-based approaches. Their ability to increase scientific insight beyond traditional candidate gene approaches, however, is usually hindered by batch effects and other sources of unwanted variation, which are particularly hard to control in the study of brain and behavior.<h4>Results</h4>We examined genome-wide gene expression ","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2026-05-02T09:04:51.32Z","creation":"2026-04-07T17:53:17.81Z"},"accession":"S-EPMC4460846","cross_references":{"pubmed":["26040834"],"doi":["10.1186/1471-2164-16-S5-S5"]}}