biostudies-literatureUnknown10(6)Dhondt A<h4>Background and objective</h4>Low molecular weight heparins (LMWHs) are small enough to pass large pore dialysis membranes. Removal of LMWH if injected before the start of the session is possible during high-flux dialysis and hemodiafiltration. The aim of this study was to determine the optimal mode (place and time) of tinzaparin administration during postdilution hemodiafiltration.<h4>Study design, setting, patients</h4>In 13 chronic hemodiafiltration patients, 3 approaches of injection were compared in a randomised cross over trial: i) before the start of the session at the inlet blood line filled with rinsing solution (IN0), ii) 5 min after the start at the inlet line filled with blood (IN5) and iii) before the start of the session at the outlet blood line (OUT0). Anti-Xa activity, tPloS onee0128634https://www.ebi.ac.uk/biostudies/studies/S-EPMC4468116biostudies-literatureWhere and When To Inject Low Molecular Weight Heparin in Hemodiafiltration? A Cross Over Randomised Trial.PMC4468116Glorieux GVanholder REloot SDhondt APauwels RDevreese KfalseWhere and When To Inject Low Molecular Weight Heparin in Hemodiafiltration? A Cross Over Randomised Trial.<h4>Background and objective</h4>Low molecular weight heparins (LMWHs) are small enough to pass large pore dialysis membranes. Removal of LMWH if injected before the start of the session is possible during high-flux dialysis and hemodiafiltration. The aim of this study was to determine the optimal mode (place and time) of tinzaparin administration during postdilution hemodiafiltration.<h4>Study design, setting, patients</h4>In 13 chronic hemodiafiltration patients, 3 approaches of injection were compared in a randomised cross over trial: i) before the start of the session at the inlet blood line filled with rinsing solution (IN0), ii) 5 min after the start at the inlet line filled with blood (IN5) and iii) before the start of the session at the outlet blood line (OUT0). Anti-Xa activity, t2015-01-01T00:00:00Z20152026-05-30T08:37:08.264Z2019-03-26T23:33:17ZS-EPMC44681162607601410.1371/journal.pone.0128634