biostudies-literatureUnknown15Steffen A<h4>Background</h4>Medically unexplained movement or sensibility disorders, recently defined in DSM-5 as functional neurological symptoms (FNS), are still insufficiently understood. Stress and trauma have been addressed as relevant factors in FNS genesis. Altered emotion processing has been discussed. The present study screened different types and times of adverse experiences in childhood and adulthood in patients with FNS as well as in healthy individuals. The relationship between stress profile, aspects of emotion processing and symptom severity was examined, with the hypothesis that particularly emotional childhood adversities would have an impact on dysfunctional emotion processing as a mediator of FNS.<h4>Methods</h4>Adverse childhood experiences (ACE), recent negative life events (LEBMC psychiatry133https://www.ebi.ac.uk/biostudies/studies/S-EPMC4477601biostudies-literature"That pulled the rug out from under my feet!" - adverse experiences and altered emotion processing in patients with functional neurological symptoms compared to healthy comparison subjects.PMC4477601Rockstroh BSchmidt RSteffen AFiess Jfalse"That pulled the rug out from under my feet!" - adverse experiences and altered emotion processing in patients with functional neurological symptoms compared to healthy comparison subjects.<h4>Background</h4>Medically unexplained movement or sensibility disorders, recently defined in DSM-5 as functional neurological symptoms (FNS), are still insufficiently understood. Stress and trauma have been addressed as relevant factors in FNS genesis. Altered emotion processing has been discussed. The present study screened different types and times of adverse experiences in childhood and adulthood in patients with FNS as well as in healthy individuals. The relationship between stress profile, aspects of emotion processing and symptom severity was examined, with the hypothesis that particularly emotional childhood adversities would have an impact on dysfunctional emotion processing as a mediator of FNS.<h4>Methods</h4>Adverse childhood experiences (ACE), recent negative life events (LE2015-01-01T00:00:00Z2015 Jun2026-07-16T00:09:00.812Z2026-07-09T10:26:06.368ZS-EPMC44776012610396110.1186/s12888-015-0514-x