biostudies-literatureGranke MBLRD VANCATS NIH HHSNIBIB NIH HHSNCRR NIH HHSNIAMS NIH HHS1290-300https://www.ebi.ac.uk/biostudies/studies/S-EPMC4478129biostudies-literatureUnknown30(7)Fracture risk does not solely depend on strength but also on fracture toughness; ie, the ability of bone material to resist crack initiation and propagation. Because resistance to crack growth largely depends on bone properties at the tissue level, including collagen characteristics, current X-ray based assessment tools may not be suitable to identify age-related, disease-related, or treatment-related changes in fracture toughness. To identify useful clinical surrogates that could improve the assessment of fracture resistance, we investigated the potential of (1)H nuclear magnetic resonance spectroscopy (NMR) and reference point indentation (RPI) to explain age-related variance in fracture toughness. Harvested from cadaveric femurs (62 human donors), single-edge notched beam (SENB) specimeJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchIdentifying Novel Clinical Surrogates to Assess Human Bone Fracture Toughness.PMC4478129AR063157UL1 RR024975R01 EB014308S10 RR027631UL1 TR0004451S10RR027631R01 AR063157I01 BX001018Makowski AJUppuganti SDoes MDNyman JSGranke MfalseIdentifying Novel Clinical Surrogates to Assess Human Bone Fracture Toughness.Fracture risk does not solely depend on strength but also on fracture toughness; ie, the ability of bone material to resist crack initiation and propagation. Because resistance to crack growth largely depends on bone properties at the tissue level, including collagen characteristics, current X-ray based assessment tools may not be suitable to identify age-related, disease-related, or treatment-related changes in fracture toughness. To identify useful clinical surrogates that could improve the assessment of fracture resistance, we investigated the potential of (1)H nuclear magnetic resonance spectroscopy (NMR) and reference point indentation (RPI) to explain age-related variance in fracture toughness. Harvested from cadaveric femurs (62 human donors), single-edge notched beam (SENB) specime2015-01-01T00:00:00Z2015 Jul2025-04-04T02:23:52.504Z2019-03-27T01:53:55ZS-EPMC44781292563962810.1002/jbmr.2452