biostudies-literatureUnknown11(4)Sawai H<h4>Unlabelled</h4>Bipolar disorder (BD) is a psychiatric disease considered to polygenic with multiple factors in genetics, each of which is not dominant but collaborative during pathogenic progression. We describe a method that estimates the collaborative contribution to the disease between a certain well-studied pathway and the other candidate pathway using Gene Set Enrichment Analysis (GSEA). We describe a modified GSEA (improved derivation) to identify genes that are significantly and differentially expressed between disease and non-disease states and that are consistently co-expressed with a target pathway which is deeply related to disease etiology. The modified GSEA uses available gene expression data to identify molecular mechanism (ubiquitin-proteasome and inflammatory response) Bioinformation207-16https://www.ebi.ac.uk/biostudies/studies/S-EPMC4479050biostudies-literatureIdentification of collaborative activities with oxidative phosphorylation in bipolar disorder.PMC4479050Tanaka HTakai-Igarashi TSawai HfalseIdentification of collaborative activities with oxidative phosphorylation in bipolar disorder.<h4>Unlabelled</h4>Bipolar disorder (BD) is a psychiatric disease considered to polygenic with multiple factors in genetics, each of which is not dominant but collaborative during pathogenic progression. We describe a method that estimates the collaborative contribution to the disease between a certain well-studied pathway and the other candidate pathway using Gene Set Enrichment Analysis (GSEA). We describe a modified GSEA (improved derivation) to identify genes that are significantly and differentially expressed between disease and non-disease states and that are consistently co-expressed with a target pathway which is deeply related to disease etiology. The modified GSEA uses available gene expression data to identify molecular mechanism (ubiquitin-proteasome and inflammatory response) 2015-01-01T00:00:00Z20152026-05-30T11:20:40.412Z2019-03-27T01:53:59ZS-EPMC44790502612456210.6026/97320630011207