{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gaudet MM"],"funding":["Intramural NIH HHS","NCI NIH HHS"],"pagination":["673-81"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4481608"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(2)"],"pubmed_abstract":["<h4>Background</h4>Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies.<h4>Methods</h4>We pooled data from 1,941,300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status.<h4>Results</h4>Greater waist circumference (per 5 cm: HR = 1.04, 95% CI 1.03-1.05, P-value for trend = <0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95% CI 1.05-1.09, P-value for trend = <0.0001), adjusted for body mass index (BMI), were associa"],"journal":["International journal of epidemiology"],"pubmed_title":["Anthropometry and head and neck cancer:a pooled analysis of cohort data."],"pmcid":["PMC4481608"],"funding_grant_id":["UM1 CA182910","Z01 ES049030","UM1 CA182913","K05 CA154337","Z01-CP010119","UM1 CA173640","Z01 CP010119"],"pubmed_authors":["Schairer C","Beane Freeman LE","Huang WY","Sesso HD","Hartge P","Boeing H","Buring J","Hakansson N","Weiderpass E","Prizment A","Park Y","Gapstur SM","Gao YT","Giles GG","Chen Y","White E","D'Aloisio AA","Adami HO","Wolk A","MacInnis RJ","Riboli E","Robien K","Yang G","Kitahara CM","Freedman M","Berrington de Gonzalez A","Kreimer AR","Gaudet MM","Patel AV","Linet MS","Reynolds P","Purdue MP","Sandler DP","Alavanja MC","Zelenuich-Jacquotte A","Zheng W","Chaturvedi A","Ou Shu X","Lee IM","Xiang YB","Newton CC","Gaziano JM","Bernstein L"],"additional_accession":[]},"is_claimable":false,"name":"Anthropometry and head and neck cancer:a pooled analysis of cohort data.","description":"<h4>Background</h4>Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies.<h4>Methods</h4>We pooled data from 1,941,300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status.<h4>Results</h4>Greater waist circumference (per 5 cm: HR = 1.04, 95% CI 1.03-1.05, P-value for trend = <0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95% CI 1.05-1.09, P-value for trend = <0.0001), adjusted for body mass index (BMI), were associa","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Apr","modification":"2025-04-05T10:12:19.658Z","creation":"2019-03-27T01:54:05Z"},"accession":"S-EPMC4481608","cross_references":{"pubmed":["26050257"],"doi":["10.1093/ije/dyv059"]}}