biostudies-literatureGaudet MMIntramural NIH HHSNCI NIH HHS673-81https://www.ebi.ac.uk/biostudies/studies/S-EPMC4481608biostudies-literatureUnknown44(2)<h4>Background</h4>Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies.<h4>Methods</h4>We pooled data from 1,941,300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status.<h4>Results</h4>Greater waist circumference (per 5 cm: HR = 1.04, 95% CI 1.03-1.05, P-value for trend = <0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95% CI 1.05-1.09, P-value for trend = <0.0001), adjusted for body mass index (BMI), were associaInternational journal of epidemiologyAnthropometry and head and neck cancer:a pooled analysis of cohort data.PMC4481608UM1 CA182910Z01 ES049030UM1 CA182913K05 CA154337Z01-CP010119UM1 CA173640Z01 CP010119Schairer CBeane Freeman LEHuang WYSesso HDHartge PBoeing HBuring JHakansson NWeiderpass EPrizment APark YGapstur SMGao YTGiles GGChen YWhite ED'Aloisio AAAdami HOWolk AMacInnis RJRiboli ERobien KYang GKitahara CMFreedman MBerrington de Gonzalez AKreimer ARGaudet MMPatel AVLinet MSReynolds PPurdue MPSandler DPAlavanja MCZelenuich-Jacquotte AZheng WChaturvedi AOu Shu XLee IMXiang YBNewton CCGaziano JMBernstein LfalseAnthropometry and head and neck cancer:a pooled analysis of cohort data.<h4>Background</h4>Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies.<h4>Methods</h4>We pooled data from 1,941,300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status.<h4>Results</h4>Greater waist circumference (per 5 cm: HR = 1.04, 95% CI 1.03-1.05, P-value for trend = <0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95% CI 1.05-1.09, P-value for trend = <0.0001), adjusted for body mass index (BMI), were associa2015-01-01T00:00:00Z2015 Apr2025-04-05T10:12:19.658Z2019-03-27T01:54:05ZS-EPMC44816082605025710.1093/ije/dyv059