{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(6)"],"submitter":["Lochead J"],"pubmed_abstract":["Time-resolved cell culture assays circumvent the need to set arbitrary end-points and reveal the dynamics of quality controlled experiments. However, they lead to the generation of large data sets, which can represent a complexity barrier to their use. We therefore developed the Time-Resolved Cell Culture Assay (TReCCA) Analyser program to perform standard cell assay analyses efficiently and make sophisticated in-depth analyses easily available. The functions of the program include data normalising and averaging, as well as smoothing and slope calculation, pin-pointing exact change time points. A time-resolved IC50/EC50 calculation provides a better understanding of drug toxicity over time and a more accurate drug to drug comparison. Finally the logarithmic sensor recalibration function, f"],"journal":["PloS one"],"pagination":["e0131233"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4482264"],"repository":["biostudies-literature"],"pubmed_title":["Time-resolved cell culture assay analyser (TReCCA Analyser) for the analysis of on-line data: data integration--sensor correction--time-resolved IC50 determination."],"pmcid":["PMC4482264"],"pubmed_authors":["Schessner J","Wolfl S","Werner T","Lochead J"],"additional_accession":[]},"is_claimable":false,"name":"Time-resolved cell culture assay analyser (TReCCA Analyser) for the analysis of on-line data: data integration--sensor correction--time-resolved IC50 determination.","description":"Time-resolved cell culture assays circumvent the need to set arbitrary end-points and reveal the dynamics of quality controlled experiments. However, they lead to the generation of large data sets, which can represent a complexity barrier to their use. We therefore developed the Time-Resolved Cell Culture Assay (TReCCA) Analyser program to perform standard cell assay analyses efficiently and make sophisticated in-depth analyses easily available. The functions of the program include data normalising and averaging, as well as smoothing and slope calculation, pin-pointing exact change time points. A time-resolved IC50/EC50 calculation provides a better understanding of drug toxicity over time and a more accurate drug to drug comparison. Finally the logarithmic sensor recalibration function, f","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2025-04-05T10:12:48.151Z","creation":"2019-03-26T23:33:27Z"},"accession":"S-EPMC4482264","cross_references":{"pubmed":["26110644"],"doi":["10.1371/journal.pone.0131233"]}}