{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(6)"],"submitter":["Hillen MR"],"pubmed_abstract":["Introduction
The cytokines interleukin (IL)-7 and thymic stromal lymphopoietin (TSLP) signal through the IL-7R subunit and play proinflammatory roles in experimental arthritis and rheumatoid arthritis (RA). We evaluated the effect of inhibition of IL-7R- and TSLPR-signalling as well as simultaneous inhibition of IL-7R- and TSLPR-signalling in murine experimental arthritis. In addition, the effects of IL-7 and TSLP in human RA dendritic cell (DC)/T-cell co-cultures were studied.Methods
Arthritis was induced with proteoglycan in wildtype mice (WT) and in mice deficient for the TSLP receptor subunit (TSLPR-/-). Both mice genotypes were treated with anti-IL-7R or phosphate buffered saline. Arthritis severity was assessed and local and circulating cytokines were measured. Autolo"],"journal":["PloS one"],"pagination":["e0130830"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4482403"],"repository":["biostudies-literature"],"pubmed_title":["The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade."],"pmcid":["PMC4482403"],"pubmed_authors":["Hillen MR","Willis CR","Lafeber FP","Radstake TR","Hack CE","Hartgring SA","van Roon JA"],"additional_accession":[]},"is_claimable":false,"name":"The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade.","description":"Introduction
The cytokines interleukin (IL)-7 and thymic stromal lymphopoietin (TSLP) signal through the IL-7R subunit and play proinflammatory roles in experimental arthritis and rheumatoid arthritis (RA). We evaluated the effect of inhibition of IL-7R- and TSLPR-signalling as well as simultaneous inhibition of IL-7R- and TSLPR-signalling in murine experimental arthritis. In addition, the effects of IL-7 and TSLP in human RA dendritic cell (DC)/T-cell co-cultures were studied.Methods
Arthritis was induced with proteoglycan in wildtype mice (WT) and in mice deficient for the TSLP receptor subunit (TSLPR-/-). Both mice genotypes were treated with anti-IL-7R or phosphate buffered saline. Arthritis severity was assessed and local and circulating cytokines were measured. Autolo","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2025-04-05T10:12:22.208Z","creation":"2019-03-26T23:33:27Z"},"accession":"S-EPMC4482403","cross_references":{"pubmed":["26110994"],"doi":["10.1371/journal.pone.0130830"]}}