{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wijchers PJ"],"funding":["EU","European Research Council","Nederlandse Organisatie voor Wetenschappelijk Onderzoek TOP","Nederlandse Organisatie voor Wetenschappelijk VICI"],"pagination":["958-69"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4484393"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(7)"],"pubmed_abstract":["Despite recent progress in genome topology knowledge, the role of repeats, which make up the majority of mammalian genomes, remains elusive. Satellite repeats are highly abundant sequences that cluster around centromeres, attract pericentromeric heterochromatin, and aggregate into nuclear chromocenters. These nuclear landmark structures are assumed to form a repressive compartment in the nucleus to which genes are recruited for silencing. We have designed a strategy for genome-wide identification of pericentromere-associated domains (PADs) in different mouse cell types. The ∼1000 PADs and non-PADs have similar chromatin states in embryonic stem cells, but during lineage commitment, chromocenters progressively associate with constitutively inactive genomic regions at the nuclear periphery. "],"journal":["Genome research"],"pubmed_title":["Characterization and dynamics of pericentromere-associated domains in mice."],"pmcid":["PMC4484393"],"funding_grant_id":["2010-259743","724.012.003","209700","714.012.002"],"pubmed_authors":["de Laat W","Schell Y","Janssen M","Zhu Y","Eyres M","Verstegen M","de Wit E","Bergsma AJ","Vermeulen C","Wijchers PJ","Geeven G"],"additional_accession":[]},"is_claimable":false,"name":"Characterization and dynamics of pericentromere-associated domains in mice.","description":"Despite recent progress in genome topology knowledge, the role of repeats, which make up the majority of mammalian genomes, remains elusive. Satellite repeats are highly abundant sequences that cluster around centromeres, attract pericentromeric heterochromatin, and aggregate into nuclear chromocenters. These nuclear landmark structures are assumed to form a repressive compartment in the nucleus to which genes are recruited for silencing. We have designed a strategy for genome-wide identification of pericentromere-associated domains (PADs) in different mouse cell types. The ∼1000 PADs and non-PADs have similar chromatin states in embryonic stem cells, but during lineage commitment, chromocenters progressively associate with constitutively inactive genomic regions at the nuclear periphery. ","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jul","modification":"2025-04-19T03:47:07.582Z","creation":"2019-06-06T14:33:11Z"},"accession":"S-EPMC4484393","cross_references":{"pubmed":["25883320"],"doi":["10.1101/gr.186643.114"]}}