{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5"],"submitter":["Ye Y"],"pubmed_abstract":["The underlying cause of neutropenia may be difficult to determine due to similar clinical presentation in many neutropenic conditions. The neutrophil protein hCAP-18 (pro-LL-37) is a major component of neutrophil secondary granules and in this prospective study we assessed the use of hCAP-18 levels in blood plasma for differential diagnosis of neutropenic patients (n = 133) of various aetiologies. Plasma levels of hCAP-18 were determined using immunoblot and ELISA. Patients with severe congenital neutropenia (n = 23) presented with the lowest levels of plasma hCAP-18 and differential diagnostic accuracy revealed high sensitivity (100%) and specificity (98.8%) for hCAP-18 ELISA. The correlation coefficient of the hCAP-18 ELISA versus immunoblotting was (R = 0.831) and that of the peptide LL"],"journal":["Scientific reports"],"pagination":["11685"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4484407"],"repository":["biostudies-literature"],"pubmed_title":["The antimicrobial propeptide hCAP-18 plasma levels in neutropenia of various aetiologies: a prospective study."],"pmcid":["PMC4484407"],"pubmed_authors":["Borregaard N","Andersson ML","Karlsson-Sjoberg JM","Modeer TU","Ye Y","Carlsson G","Putsep KL"],"additional_accession":[]},"is_claimable":false,"name":"The antimicrobial propeptide hCAP-18 plasma levels in neutropenia of various aetiologies: a prospective study.","description":"The underlying cause of neutropenia may be difficult to determine due to similar clinical presentation in many neutropenic conditions. The neutrophil protein hCAP-18 (pro-LL-37) is a major component of neutrophil secondary granules and in this prospective study we assessed the use of hCAP-18 levels in blood plasma for differential diagnosis of neutropenic patients (n = 133) of various aetiologies. Plasma levels of hCAP-18 were determined using immunoblot and ELISA. Patients with severe congenital neutropenia (n = 23) presented with the lowest levels of plasma hCAP-18 and differential diagnostic accuracy revealed high sensitivity (100%) and specificity (98.8%) for hCAP-18 ELISA. The correlation coefficient of the hCAP-18 ELISA versus immunoblotting was (R = 0.831) and that of the peptide LL","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jun","modification":"2025-04-04T19:47:28.653Z","creation":"2019-03-27T01:54:10Z"},"accession":"S-EPMC4484407","cross_references":{"pubmed":["26119962"],"doi":["10.1038/srep11685"]}}