{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aftab Q"],"funding":["Canadian Institutes of Health Research"],"pagination":["11447-64"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4484468"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(13)"],"pubmed_abstract":["Glioblastoma Multiforme (GBM), an aggressive form of adult brain tumor, is difficult to treat due to its invasive nature. One of the molecular changes observed in GBM is a decrease in the expression of the gap junction protein Connexin43 (Cx43); however, how a reduction in Cx43 expression contributes to glioma malignancy is still unclear. In this study we examine whether a decrease in Cx43 protein expression has a role in enhanced cell migration, a key feature associated with increased tumorigenicity. We used a 3D spheroid migration model that mimics the in vivo architecture of tumor cells to quantify migration changes. We found that down-regulation of Cx43 expression in the U118 human glioma cell line increased migration by reducing cell-ECM adhesion, and changed the migration pattern fro"],"journal":["Oncotarget"],"pubmed_title":["Reduction in gap junction intercellular communication promotes glioma migration."],"pmcid":["PMC4484468"],"funding_grant_id":["MOP-102489","MOP-93572"],"pubmed_authors":["Aftab Q","Sin WC","Naus CC"],"additional_accession":[]},"is_claimable":false,"name":"Reduction in gap junction intercellular communication promotes glioma migration.","description":"Glioblastoma Multiforme (GBM), an aggressive form of adult brain tumor, is difficult to treat due to its invasive nature. One of the molecular changes observed in GBM is a decrease in the expression of the gap junction protein Connexin43 (Cx43); however, how a reduction in Cx43 expression contributes to glioma malignancy is still unclear. In this study we examine whether a decrease in Cx43 protein expression has a role in enhanced cell migration, a key feature associated with increased tumorigenicity. We used a 3D spheroid migration model that mimics the in vivo architecture of tumor cells to quantify migration changes. We found that down-regulation of Cx43 expression in the U118 human glioma cell line increased migration by reducing cell-ECM adhesion, and changed the migration pattern fro","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 May","modification":"2025-04-05T10:12:58.698Z","creation":"2019-03-27T01:54:11Z"},"accession":"S-EPMC4484468","cross_references":{"pubmed":["25926558"],"doi":["10.18632/oncotarget.3407"]}}