biostudies-literatureUnknown3(4)Xiao SJNumerous studies have investigated the prognostic role of brain and acute leukemia, cytoplasmic (<i>BAALC</i>) gene expression in adult patients with acute myeloid leukemia (AML); however, the results are inconclusive. A meta-analysis was conducted to provide a comprehensive evaluation of the prognostic role of <i>BAALC</i> gene expression in AML. Eligible studies were searched through PubMed, Embase, the Cochrane Library, the China National Knowledge Infrastructure and the China Biology Medicine Disc. Correlations between the <i>BAALC</i> gene expression and clinicopathological features and prognosis were analyzed. A total of 15 studies were examined. The pooled results suggest that high <i>BAALC</i> expression had an unfavorable outcome in AML. The combined hazard ratio (HR) for overall survival (OS) was 1.53 and the summary HR for the disease-free survival rate was 1.64. In addition, subgroup analyses considering cytogenetic and survival analysis were also conducted. High <i>BAALC</i> gene expression appeared to be an adverse prognostic indicator in patients with cytogenetically normal AML (HR for OS, 1.43) and in subgroups of survival analysis with multivariate analysis (HR for OS, 2.35). These results indicate that high <i>BAALC gene</i> expression served as an independent poor prognostic indicator in adult patients with AML.Molecular and clinical oncology880-888https://www.ebi.ac.uk/biostudies/studies/S-EPMC4486884biostudies-literaturePrognostic significance of the <i>BAALC</i> gene expression in adult patients with acute myeloid leukemia: A meta-analysis.PMC4486884Fu HYXiao SJHuang JLShen JZfalsePrognostic significance of the <i>BAALC</i> gene expression in adult patients with acute myeloid leukemia: A meta-analysis.Numerous studies have investigated the prognostic role of brain and acute leukemia, cytoplasmic (<i>BAALC</i>) gene expression in adult patients with acute myeloid leukemia (AML); however, the results are inconclusive. A meta-analysis was conducted to provide a comprehensive evaluation of the prognostic role of <i>BAALC</i> gene expression in AML. Eligible studies were searched through PubMed, Embase, the Cochrane Library, the China National Knowledge Infrastructure and the China Biology Medicine Disc. Correlations between the <i>BAALC</i> gene expression and clinicopathological features and prognosis were analyzed. A total of 15 studies were examined. The pooled results suggest that high <i>BAALC</i> expression had an unfavorable outcome in AML. The combined hazard ratio (HR) for overall survival (OS) was 1.53 and the summary HR for the disease-free survival rate was 1.64. In addition, subgroup analyses considering cytogenetic and survival analysis were also conducted. High <i>BAALC</i> gene expression appeared to be an adverse prognostic indicator in patients with cytogenetically normal AML (HR for OS, 1.43) and in subgroups of survival analysis with multivariate analysis (HR for OS, 2.35). These results indicate that high <i>BAALC gene</i> expression served as an independent poor prognostic indicator in adult patients with AML.2015-01-01T00:00:00Z2015 Jul2024-11-07T12:25:46.782Z2019-03-27T01:54:18ZS-EPMC44868842617120010.3892/mco.2015.562