biostudies-literatureUnknown5Mir AAFungal pathogens have evolved antioxidant defense against reactive oxygen species produced as a part of host innate immunity. Recent studies proposed peroxidases as components of antioxidant defense system. However, the role of fungal peroxidases during interaction with host plants has not been explored at the genomic level. Here, we systematically identified peroxidase genes and analyzed their impact on fungal pathogenesis in a model plant pathogenic fungus, Magnaporthe oryzae. Phylogeny reconstruction placed 27 putative peroxidase genes into 15 clades. Expression profiles showed that majority of them are responsive to in planta condition and in vitro H2O2. Our analysis of individual deletion mutants for seven selected genes including MoPRX1 revealed that these genes contribute to fungal Scientific reports11831https://www.ebi.ac.uk/biostudies/studies/S-EPMC4488832biostudies-literatureSystematic characterization of the peroxidase gene family provides new insights into fungal pathogenicity in Magnaporthe oryzae.PMC4488832Kim SMir AAChoi JPark SYJeon JLee YHAbu Sadat MfalseSystematic characterization of the peroxidase gene family provides new insights into fungal pathogenicity in Magnaporthe oryzae.Fungal pathogens have evolved antioxidant defense against reactive oxygen species produced as a part of host innate immunity. Recent studies proposed peroxidases as components of antioxidant defense system. However, the role of fungal peroxidases during interaction with host plants has not been explored at the genomic level. Here, we systematically identified peroxidase genes and analyzed their impact on fungal pathogenesis in a model plant pathogenic fungus, Magnaporthe oryzae. Phylogeny reconstruction placed 27 putative peroxidase genes into 15 clades. Expression profiles showed that majority of them are responsive to in planta condition and in vitro H2O2. Our analysis of individual deletion mutants for seven selected genes including MoPRX1 revealed that these genes contribute to fungal 2015-01-01T00:00:00Z2015 Jul2026-05-30T13:17:02.062Z2019-03-27T01:54:23ZS-EPMC44888322613497410.1038/srep11831