{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Espinet B"],"funding":["NIAID NIH HHS"],"pagination":["1007-19"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4488901"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(4)"],"pubmed_abstract":["Purpose
According to current diagnostic criteria, mantle cell lymphoma (MCL) encompasses the usual, aggressive variants and rare, nonnodal cases with monoclonal asymptomatic lymphocytosis, cyclin D1-positive (MALD1). We aimed to understand the biology behind this clinical heterogeneity and to identify markers for adequate identification of MALD1 cases.Experimental design
We compared 17 typical MCL cases with a homogeneous group of 13 untreated MALD1 cases (median follow-up, 71 months). We conducted gene expression profiling with functional analysis in five MCL and five MALD1. Results were validated in 12 MCL and 8 MALD1 additional cases by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and in 24 MCL and 13 MALD1 cases by flow cytometry. Classificatio"],"journal":["Clinical cancer research : an official journal of the American Association for Cancer Research"],"pubmed_title":["Distinction between asymptomatic monoclonal B-cell lymphocytosis with cyclin D1 overexpression and mantle cell lymphoma: from molecular profiling to flow cytometry."],"pmcid":["PMC4488901"],"funding_grant_id":["R01 AI057653"],"pubmed_authors":["Serrano S","Ferrer A","Sanz F","Bellosillo B","Orfao A","Navarro JT","Garcia-Garcia M","Florensa L","Salar A","Luno E","Gimeno J","Nonell L","Abrisqueta P","Cerutti A","Espinet B","Lloreta J","Dominguez-Sola D","Sole F","Minana B","de la Banda E","Arenillas L","Collado R","Serrano C","Fernandez-Rodriguez C","Puigdecanet E","Vela MC"],"additional_accession":[]},"is_claimable":false,"name":"Distinction between asymptomatic monoclonal B-cell lymphocytosis with cyclin D1 overexpression and mantle cell lymphoma: from molecular profiling to flow cytometry.","description":"Purpose
According to current diagnostic criteria, mantle cell lymphoma (MCL) encompasses the usual, aggressive variants and rare, nonnodal cases with monoclonal asymptomatic lymphocytosis, cyclin D1-positive (MALD1). We aimed to understand the biology behind this clinical heterogeneity and to identify markers for adequate identification of MALD1 cases.Experimental design
We compared 17 typical MCL cases with a homogeneous group of 13 untreated MALD1 cases (median follow-up, 71 months). We conducted gene expression profiling with functional analysis in five MCL and five MALD1. Results were validated in 12 MCL and 8 MALD1 additional cases by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and in 24 MCL and 13 MALD1 cases by flow cytometry. Classificatio","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Feb","modification":"2026-05-30T13:42:18.62Z","creation":"2026-04-08T07:20:07.692Z"},"accession":"S-EPMC4488901","cross_references":{"pubmed":["24352646"],"doi":["10.1158/1078-0432.CCR-13-1077","10.1158/1078-0432.ccr-13-1077"]}}