biostudies-literatureUnknown2015Piccaluga PPUniversity of BolognaThe interferon-inducible DNA sensor IFI16 is involved in the modulation of cellular survival, proliferation, and differentiation. In the hematopoietic system, IFI16 is consistently expressed in the CD34+ stem cells and in peripheral blood lymphocytes; however, little is known regarding its regulation during maturation of B- and T-cells. We explored the role of IFI16 in normal B-cell subsets by analysing its expression and relationship with the major transcription factors involved in germinal center (GC) development and plasma-cell (PC) maturation. IFI16 mRNA was differentially expressed in B-cell subsets with significant decrease in IFI16 mRNA in GC and PCs with respect to naïve and memory subsets. IFI16 mRNA expression is inversely correlated with a few master regulators of B-cell differeJournal of immunology research747645https://www.ebi.ac.uk/biostudies/studies/S-EPMC4491573biostudies-literatureIFI16 Expression Is Related to Selected Transcription Factors during B-Cell Differentiation.PMC4491573Clo ATripodo CMiserocchi APileri SARighi SPiccin OGariglio MFuligni FFerri GGRe MCLandolfo SPiccaluga PPRinaldi-Ceroni AMorini SAgostinelli CDe Andrea MGibellini DfalseIFI16 Expression Is Related to Selected Transcription Factors during B-Cell Differentiation.The interferon-inducible DNA sensor IFI16 is involved in the modulation of cellular survival, proliferation, and differentiation. In the hematopoietic system, IFI16 is consistently expressed in the CD34+ stem cells and in peripheral blood lymphocytes; however, little is known regarding its regulation during maturation of B- and T-cells. We explored the role of IFI16 in normal B-cell subsets by analysing its expression and relationship with the major transcription factors involved in germinal center (GC) development and plasma-cell (PC) maturation. IFI16 mRNA was differentially expressed in B-cell subsets with significant decrease in IFI16 mRNA in GC and PCs with respect to naïve and memory subsets. IFI16 mRNA expression is inversely correlated with a few master regulators of B-cell differe2015-01-01T00:00:00Z20152026-05-30T12:02:08.365Z2019-03-27T01:54:32ZS-EPMC44915732618577010.1155/2015/747645