{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Muto K"],"pubmed_abstract":["The Suzuki-Miyaura cross-coupling is a metal-catalysed reaction in which boron-based nucleophiles and halide-based electrophiles are reacted to form a single molecule. This is one of the most reliable tools in synthetic chemistry, and is extensively used in the synthesis of pharmaceuticals, agrochemicals and organic materials. Herein, we report a significant advance in the choice of electrophilic coupling partner in this reaction. With a user-friendly and inexpensive nickel catalyst, a range of phenyl esters of aromatic, heteroaromatic and aliphatic carboxylic acids react with boronic acids in a decarbonylative manner. Overall, phenyl ester moieties function as leaving groups. Theoretical calculations uncovered key mechanistic features of this unusual decarbonylative coupling. Since extrao"],"journal":["Nature communications"],"pagination":["7508"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4491840"],"repository":["biostudies-literature"],"pubmed_title":["Decarbonylative organoboron cross-coupling of esters by nickel catalysis."],"pmcid":["PMC4491840"],"pubmed_authors":["Muto K","Musaev DG","Yamaguchi J","Itami K"],"additional_accession":[]},"is_claimable":false,"name":"Decarbonylative organoboron cross-coupling of esters by nickel catalysis.","description":"The Suzuki-Miyaura cross-coupling is a metal-catalysed reaction in which boron-based nucleophiles and halide-based electrophiles are reacted to form a single molecule. This is one of the most reliable tools in synthetic chemistry, and is extensively used in the synthesis of pharmaceuticals, agrochemicals and organic materials. Herein, we report a significant advance in the choice of electrophilic coupling partner in this reaction. With a user-friendly and inexpensive nickel catalyst, a range of phenyl esters of aromatic, heteroaromatic and aliphatic carboxylic acids react with boronic acids in a decarbonylative manner. Overall, phenyl ester moieties function as leaving groups. Theoretical calculations uncovered key mechanistic features of this unusual decarbonylative coupling. Since extrao","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jun","modification":"2026-05-01T14:49:26.874Z","creation":"2019-03-27T01:54:35Z"},"accession":"S-EPMC4491840","cross_references":{"pubmed":["26118733"],"doi":["10.1038/ncomms8508"]}}