biostudies-literatureDillon DGNIMH NIH HHS2333-44https://www.ebi.ac.uk/biostudies/studies/S-EPMC4499007biostudies-literatureUnknown45(11)<h4>Background</h4>Depression is characterized by poor executive function, but - counterintuitively - in some studies, it has been associated with highly accurate performance on certain cognitively demanding tasks. The psychological mechanisms responsible for this paradoxical finding are unclear. To address this issue, we applied a drift diffusion model (DDM) to flanker task data from depressed and healthy adults participating in the multi-site Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care for Depression (EMBARC) study.<h4>Method</h4>One hundred unmedicated, depressed adults and 40 healthy controls completed a flanker task. We investigated the effect of flanker interference on accuracy and response time, and used the DDM to examine group differencesPsychological medicineA computational analysis of flanker interference in depression.PMC4499007U01 MH092250R00MH094438U01MH092221U01 MH092221U01MH092250R00 MH094438Webb CWeissman MMcGrath PJCusin CGoer FOquendo MAPizzagalli DADeldin PTrivedi MMcInnis MToups MWiecki TFava MCarmody TWeyandt SAdams PBruder GShores-Wilson KDillon DGMurray LPechtel PParsey RKurian BfalseA computational analysis of flanker interference in depression.<h4>Background</h4>Depression is characterized by poor executive function, but - counterintuitively - in some studies, it has been associated with highly accurate performance on certain cognitively demanding tasks. The psychological mechanisms responsible for this paradoxical finding are unclear. To address this issue, we applied a drift diffusion model (DDM) to flanker task data from depressed and healthy adults participating in the multi-site Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care for Depression (EMBARC) study.<h4>Method</h4>One hundred unmedicated, depressed adults and 40 healthy controls completed a flanker task. We investigated the effect of flanker interference on accuracy and response time, and used the DDM to examine group differences2015-01-01T00:00:00Z2015 Aug2026-05-30T10:36:32.509Z2019-03-27T01:54:58ZS-EPMC44990072572737510.1017/S003329171500027610.1017/s0033291715000276