{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Aliloo H"],"pubmed_abstract":["<h4>Background</h4>It has been suggested that traits with low heritability, such as fertility, may have proportionately more genetic variation arising from non-additive effects than traits with higher heritability, such as milk yield. Here, we performed a large genome scan with 408,255 single nucleotide polymorphism (SNP) markers to identify chromosomal regions associated with additive, dominance and epistatic (pairwise additive × additive) variability in milk yield and a measure of fertility, calving interval, using records from a population of 7,055 Holstein cows. The results were subsequently validated in an independent set of 3,795 Jerseys.<h4>Results</h4>We identified genomic regions with validated additive effects on milk yield on Bos taurus autosomes (BTA) 5, 14 and 20, whereas SNPs"],"journal":["BMC genetics"],"pagination":["89"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4509610"],"repository":["biostudies-literature"],"pubmed_title":["Validation of markers with non-additive effects on milk yield and fertility in Holstein and Jersey cows."],"pmcid":["PMC4509610"],"pubmed_authors":["Pryce JE","Gonzalez-Recio O","Hayes BJ","Aliloo H","Cocks BG"],"additional_accession":[]},"is_claimable":false,"name":"Validation of markers with non-additive effects on milk yield and fertility in Holstein and Jersey cows.","description":"<h4>Background</h4>It has been suggested that traits with low heritability, such as fertility, may have proportionately more genetic variation arising from non-additive effects than traits with higher heritability, such as milk yield. Here, we performed a large genome scan with 408,255 single nucleotide polymorphism (SNP) markers to identify chromosomal regions associated with additive, dominance and epistatic (pairwise additive × additive) variability in milk yield and a measure of fertility, calving interval, using records from a population of 7,055 Holstein cows. The results were subsequently validated in an independent set of 3,795 Jerseys.<h4>Results</h4>We identified genomic regions with validated additive effects on milk yield on Bos taurus autosomes (BTA) 5, 14 and 20, whereas SNPs","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jul","modification":"2025-04-04T10:30:10.59Z","creation":"2019-03-27T01:55:34Z"},"accession":"S-EPMC4509610","cross_references":{"pubmed":["26193888"],"doi":["10.1186/s12863-015-0241-9"]}}