biostudies-literatureUnknown16Aliloo H<h4>Background</h4>It has been suggested that traits with low heritability, such as fertility, may have proportionately more genetic variation arising from non-additive effects than traits with higher heritability, such as milk yield. Here, we performed a large genome scan with 408,255 single nucleotide polymorphism (SNP) markers to identify chromosomal regions associated with additive, dominance and epistatic (pairwise additive × additive) variability in milk yield and a measure of fertility, calving interval, using records from a population of 7,055 Holstein cows. The results were subsequently validated in an independent set of 3,795 Jerseys.<h4>Results</h4>We identified genomic regions with validated additive effects on milk yield on Bos taurus autosomes (BTA) 5, 14 and 20, whereas SNPsBMC genetics89https://www.ebi.ac.uk/biostudies/studies/S-EPMC4509610biostudies-literatureValidation of markers with non-additive effects on milk yield and fertility in Holstein and Jersey cows.PMC4509610Pryce JEGonzalez-Recio OHayes BJAliloo HCocks BGfalseValidation of markers with non-additive effects on milk yield and fertility in Holstein and Jersey cows.<h4>Background</h4>It has been suggested that traits with low heritability, such as fertility, may have proportionately more genetic variation arising from non-additive effects than traits with higher heritability, such as milk yield. Here, we performed a large genome scan with 408,255 single nucleotide polymorphism (SNP) markers to identify chromosomal regions associated with additive, dominance and epistatic (pairwise additive × additive) variability in milk yield and a measure of fertility, calving interval, using records from a population of 7,055 Holstein cows. The results were subsequently validated in an independent set of 3,795 Jerseys.<h4>Results</h4>We identified genomic regions with validated additive effects on milk yield on Bos taurus autosomes (BTA) 5, 14 and 20, whereas SNPs2015-01-01T00:00:00Z2015 Jul2025-04-04T10:30:10.59Z2019-03-27T01:55:34ZS-EPMC45096102619388810.1186/s12863-015-0241-9