{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Burgess KS"],"funding":["Intramural NIH HHS","NICHD NIH HHS","NCATS NIH HHS","NIDDK NIH HHS","NLM NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["205-15"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4512918"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["98(2)"],"pubmed_abstract":["Developmental changes in the liver can significantly impact drug disposition. Due to the emergence of microRNAs (miRNAs) as important regulators of drug disposition gene expression, we studied age-dependent changes in miRNA expression. Expression of 533 miRNAs was measured in 90 human liver tissues (fetal, pediatric [1-17 years], and adult [28-80 years]; n = 30 each). In all, 114 miRNAs were upregulated and 72 were downregulated from fetal to pediatric, and 2 and 3, respectively, from pediatric to adult. Among the developmentally changing miRNAs, 99 miRNA-mRNA interactions were predicted or experimentally validated (e.g., hsa-miR-125b-5p-CYP1A1; hsa-miR-34a-5p-HNF4A). In human liver samples (n = 10 each), analyzed by RNA-sequencing, significant negative correlations were observed between the expression of >1,000 miRNAs and mRNAs of drug disposition and regulatory genes. Our data suggest a mechanism for the marked changes in hepatic gene expression between the fetal and pediatric developmental periods, and support a role for these age-dependent miRNAs in regulating drug disposition."],"journal":["Clinical pharmacology and therapeutics"],"pubmed_title":["Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver."],"pmcid":["PMC4512918"],"funding_grant_id":["Z01 HD008836","R01 GM088076","R01GM088076","F31 GM119401","HHSN267200700004G","5R24HD0008836","N01-DK-7-0004/HHSN267200700004C","HHSN267200700004C","UL1 TR001108"],"pubmed_authors":["Benson EA","Segar MW","Liu Y","Desta Z","Philips S","Gaedigk R","Skaar TC","Burgess KS","Gaedigk A"],"additional_accession":[]},"is_claimable":false,"name":"Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver.","description":"Developmental changes in the liver can significantly impact drug disposition. Due to the emergence of microRNAs (miRNAs) as important regulators of drug disposition gene expression, we studied age-dependent changes in miRNA expression. Expression of 533 miRNAs was measured in 90 human liver tissues (fetal, pediatric [1-17 years], and adult [28-80 years]; n = 30 each). In all, 114 miRNAs were upregulated and 72 were downregulated from fetal to pediatric, and 2 and 3, respectively, from pediatric to adult. Among the developmentally changing miRNAs, 99 miRNA-mRNA interactions were predicted or experimentally validated (e.g., hsa-miR-125b-5p-CYP1A1; hsa-miR-34a-5p-HNF4A). In human liver samples (n = 10 each), analyzed by RNA-sequencing, significant negative correlations were observed between the expression of >1,000 miRNAs and mRNAs of drug disposition and regulatory genes. Our data suggest a mechanism for the marked changes in hepatic gene expression between the fetal and pediatric developmental periods, and support a role for these age-dependent miRNAs in regulating drug disposition.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Aug","modification":"2024-11-19T22:16:27.137Z","creation":"2019-03-27T01:55:44Z"},"accession":"S-EPMC4512918","cross_references":{"pubmed":["25968989"],"doi":["10.1002/cpt.145"]}}