biostudies-literatureMyckatyn TMNCATS NIH HHSNCI NIH HHS43e-57ehttps://www.ebi.ac.uk/biostudies/studies/S-EPMC4515029biostudies-literatureUnknown135(1)<h4>Background</h4>An acellular dermal matrix will typically incorporate, in time, with the overlying mastectomy skin flap. This remodeling process may be adversely impacted in patients who require chemotherapy and radiation, which influence neovascularization and cellular proliferation.<h4>Methods</h4>Multiple biopsy specimens were procured from 86 women (n = 94 breasts) undergoing exchange of a tissue expander for a breast implant. These were divided by biopsy location: submuscular capsule (control) as well as superiorly, centrally, and inferiorly along the paramedian acellular dermis. Specimens were assessed for cellular infiltration, cell type, fibrous encapsulation, scaffold degradation, extracellular matrix deposition, neovascularization, mean composite remodeling score, and type I aPlastic and reconstructive surgeryThe impact of chemotherapy and radiation therapy on the remodeling of acellular dermal matrices in staged, prosthetic breast reconstruction.PMC4515029P30 CA091842UL1TR000448KM1 CA156708KM1CA156708P30CA091842UL1 TR000448Myckatyn TMTenenbaum MMGangopadhyay NDudas JRRoma AASharma KMatthews BDDeeken CRCavallo JABaalman SfalseThe impact of chemotherapy and radiation therapy on the remodeling of acellular dermal matrices in staged, prosthetic breast reconstruction.<h4>Background</h4>An acellular dermal matrix will typically incorporate, in time, with the overlying mastectomy skin flap. This remodeling process may be adversely impacted in patients who require chemotherapy and radiation, which influence neovascularization and cellular proliferation.<h4>Methods</h4>Multiple biopsy specimens were procured from 86 women (n = 94 breasts) undergoing exchange of a tissue expander for a breast implant. These were divided by biopsy location: submuscular capsule (control) as well as superiorly, centrally, and inferiorly along the paramedian acellular dermis. Specimens were assessed for cellular infiltration, cell type, fibrous encapsulation, scaffold degradation, extracellular matrix deposition, neovascularization, mean composite remodeling score, and type I a2015-01-01T00:00:00Z2015 Jan2026-05-30T11:08:49.72Z2019-03-27T01:55:48ZS-EPMC45150292553935010.1097/prs.000000000000080710.1097/PRS.0000000000000807