{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5"],"submitter":["Violi F"],"pubmed_abstract":["<h4>Objectives</h4>Extra virgin olive oil (EVOO) is a key component of the Mediterranean diet and seems to account for the protective effect against cardiovascular disease. However, the underlying mechanism is still elusive.<h4>Design</h4>We tested the effect of EVOO, added to Mediterranean-type meal, on post-prandial glycemic and lipid profile.<h4>Subjects</h4>Post-prandial glycemic and lipid profile were investigated in 25 healthy subjects who were randomly allocated in a cross-over design to a Mediterranean-type meal added with or without 10 g EVOO (first study), or Mediterranean-type meal with EVOO (10 g) or corn oil (10 g; second study). Glycemic profile, which included glucose, insulin, dipeptidyl-peptidase-4 (DPP-4) protein and activity, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), and lipid profile, which included, low-density lipoprotein (LDL) cholesterol (LDL-C), oxidized LDL (ox-LDL), triglycerides and high-density lipoprotein (HDL) cholesterol (HDL-C), were analyzed before and 2 h after the meal.<h4>Results</h4>In the first study, 2 h after meal, subjects who assumed a meal with EVOO had significantly lower blood glucose (P<0.001), DPP-4 protein (P<0.001) and activity (P<0.001), LDL-C (P<0.001) and ox-LDL (P<0.001) and higher insulin (P<0.05), GLP-1 (P<0.001) and GIP (P<0.05) compared with those without EVOO. The second study showed that compared with corn oil, EVOO improved both glycemic and lipid profile. Thus, a significantly smaller increase of glucose (P<0.05), DPP4 protein (P<0.001) and activity (P<0.05) and higher increase of insulin (P<0.001) and GLP-1 (P<0.001) were observed. Furthermore, compared with corn oil, EVOO showed a significantly less increase of LDL-C (P<0.05) and ox-LDL (P<0.001).<h4>Conclusions</h4>We report for the first time that EVOO improves post-prandial glucose and LDL-C, an effect that may account for the antiatherosclerotic effect of the Mediterranean diet."],"journal":["Nutrition & diabetes"],"pagination":["e172"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4521177"],"repository":["biostudies-literature"],"pubmed_title":["Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects."],"pmcid":["PMC4521177"],"pubmed_authors":["Nocella C","Cangemi R","Carnevale R","Angelico F","Loffredo L","Bartimoccia S","Petruccioli A","Violi F","Monticolo R","Pastori D","Pignatelli P"],"additional_accession":[]},"is_claimable":false,"name":"Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects.","description":"<h4>Objectives</h4>Extra virgin olive oil (EVOO) is a key component of the Mediterranean diet and seems to account for the protective effect against cardiovascular disease. However, the underlying mechanism is still elusive.<h4>Design</h4>We tested the effect of EVOO, added to Mediterranean-type meal, on post-prandial glycemic and lipid profile.<h4>Subjects</h4>Post-prandial glycemic and lipid profile were investigated in 25 healthy subjects who were randomly allocated in a cross-over design to a Mediterranean-type meal added with or without 10 g EVOO (first study), or Mediterranean-type meal with EVOO (10 g) or corn oil (10 g; second study). Glycemic profile, which included glucose, insulin, dipeptidyl-peptidase-4 (DPP-4) protein and activity, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), and lipid profile, which included, low-density lipoprotein (LDL) cholesterol (LDL-C), oxidized LDL (ox-LDL), triglycerides and high-density lipoprotein (HDL) cholesterol (HDL-C), were analyzed before and 2 h after the meal.<h4>Results</h4>In the first study, 2 h after meal, subjects who assumed a meal with EVOO had significantly lower blood glucose (P<0.001), DPP-4 protein (P<0.001) and activity (P<0.001), LDL-C (P<0.001) and ox-LDL (P<0.001) and higher insulin (P<0.05), GLP-1 (P<0.001) and GIP (P<0.05) compared with those without EVOO. The second study showed that compared with corn oil, EVOO improved both glycemic and lipid profile. Thus, a significantly smaller increase of glucose (P<0.05), DPP4 protein (P<0.001) and activity (P<0.05) and higher increase of insulin (P<0.001) and GLP-1 (P<0.001) were observed. Furthermore, compared with corn oil, EVOO showed a significantly less increase of LDL-C (P<0.05) and ox-LDL (P<0.001).<h4>Conclusions</h4>We report for the first time that EVOO improves post-prandial glucose and LDL-C, an effect that may account for the antiatherosclerotic effect of the Mediterranean diet.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jul","modification":"2024-02-15T06:20:22.589Z","creation":"2019-03-27T01:56:06Z"},"accession":"S-EPMC4521177","cross_references":{"pubmed":["26192450"],"doi":["10.1038/nutd.2015.23"]}}