{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4"],"submitter":["Lefevre L"],"pubmed_abstract":["Adrenocortical cancer (ACC) is a very aggressive tumor, and genomics studies demonstrate that the most frequent alterations of driver genes in these cancers activate the Wnt/β-catenin signaling pathway. However, the adrenal-specific targets of oncogenic β-catenin-mediating tumorigenesis have not being established. A combined transcriptomic analysis from two series of human tumors and the human ACC cell line H295R harboring a spontaneous β-catenin activating mutation was done to identify the Wnt/β-catenin targets. Seven genes were consistently identified in the three studies. Among these genes, we found that AFF3 mediates the oncogenic effects of β-catenin in ACC. The Wnt response element site located at nucleotide position -1408 of the AFF3 transcriptional start sites (TSS) mediates the re"],"journal":["Oncogenesis"],"pagination":["e161"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4521181"],"repository":["biostudies-literature"],"pubmed_title":["Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma."],"pmcid":["PMC4521181"],"pubmed_authors":["Perlemoine K","Blugeon C","Bertherat J","Lefevre L","Ragazzon B","Hantel C","Beuschlein F","Drougat L","Val P","Rodriguez S","Giraud M","Omeiri H","de Reynies A","Rizk-Rabin M"],"additional_accession":[]},"is_claimable":false,"name":"Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma.","description":"Adrenocortical cancer (ACC) is a very aggressive tumor, and genomics studies demonstrate that the most frequent alterations of driver genes in these cancers activate the Wnt/β-catenin signaling pathway. However, the adrenal-specific targets of oncogenic β-catenin-mediating tumorigenesis have not being established. A combined transcriptomic analysis from two series of human tumors and the human ACC cell line H295R harboring a spontaneous β-catenin activating mutation was done to identify the Wnt/β-catenin targets. Seven genes were consistently identified in the three studies. Among these genes, we found that AFF3 mediates the oncogenic effects of β-catenin in ACC. The Wnt response element site located at nucleotide position -1408 of the AFF3 transcriptional start sites (TSS) mediates the re","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jul","modification":"2026-05-30T03:44:05.87Z","creation":"2019-03-27T01:56:07Z"},"accession":"S-EPMC4521181","cross_references":{"pubmed":["26214578"],"doi":["10.1038/oncsis.2015.20"]}}