{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Whiting N"],"funding":["NCI NIH HHS"],"pagination":["12842"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4523869"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5"],"pubmed_abstract":["Visualizing the movement of angiocatheters during endovascular interventions is typically accomplished using x-ray fluoroscopy. There are many potential advantages to developing magnetic resonance imaging-based approaches that will allow three-dimensional imaging of the tissue/vasculature interface while monitoring other physiologically-relevant criteria, without exposing the patient or clinician team to ionizing radiation. Here we introduce a proof-of-concept development of a magnetic resonance imaging-guided catheter tracking method that utilizes hyperpolarized silicon particles. The increased signal of the silicon particles is generated via low-temperature, solid-state dynamic nuclear polarization, and the particles retain their enhanced signal for ≥ 40 minutes--allowing imaging experiments over extended time durations. The particles are affixed to the tip of standard medical-grade catheters and are used to track passage under set distal and temporal points in phantoms and live mouse models. With continued development, this method has the potential to supplement x-ray fluoroscopy and other MRI-guided catheter tracking methods as a zero-background, positive contrast agent that does not require ionizing radiation."],"journal":["Scientific reports"],"pubmed_title":["Real-Time MRI-Guided Catheter Tracking Using Hyperpolarized Silicon Particles."],"pmcid":["PMC4523869"],"funding_grant_id":["CA016672","P30 CA016672","U54 CA151668","R21 CA185536","R25T CA057730","R25 CA057730","U54CA151668-03"],"pubmed_authors":["Millward NZ","Whiting N","Shah JV","Marcus CM","Hu J","Menter DG","Bhattacharya PK","Cassidy MC","Cressman E"],"additional_accession":[]},"is_claimable":false,"name":"Real-Time MRI-Guided Catheter Tracking Using Hyperpolarized Silicon Particles.","description":"Visualizing the movement of angiocatheters during endovascular interventions is typically accomplished using x-ray fluoroscopy. There are many potential advantages to developing magnetic resonance imaging-based approaches that will allow three-dimensional imaging of the tissue/vasculature interface while monitoring other physiologically-relevant criteria, without exposing the patient or clinician team to ionizing radiation. Here we introduce a proof-of-concept development of a magnetic resonance imaging-guided catheter tracking method that utilizes hyperpolarized silicon particles. The increased signal of the silicon particles is generated via low-temperature, solid-state dynamic nuclear polarization, and the particles retain their enhanced signal for ≥ 40 minutes--allowing imaging experiments over extended time durations. The particles are affixed to the tip of standard medical-grade catheters and are used to track passage under set distal and temporal points in phantoms and live mouse models. With continued development, this method has the potential to supplement x-ray fluoroscopy and other MRI-guided catheter tracking methods as a zero-background, positive contrast agent that does not require ionizing radiation.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Aug","modification":"2025-04-26T18:10:15.841Z","creation":"2019-03-27T01:56:13Z"},"accession":"S-EPMC4523869","cross_references":{"pubmed":["26239953"],"doi":["10.1038/srep12842"]}}