{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Martin V"],"funding":["Medical Research Council","Biotechnology and Biological Sciences Research Council"],"pagination":["20140237"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4528414"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["370(1676)"],"pubmed_abstract":["Older people are more susceptible to infection, less responsive to vaccination and have a more inflammatory immune environment. Using spectratype analysis, we have previously shown that the B-cell repertoire of older people shows evidence of inappropriate clonal expansions in the absence of challenge, and that this loss of B-cell diversity correlates with poor health. Studies on response to vaccination, using both spectratyping and high-throughput sequencing of the repertoire, indicate that older responses to challenge are lacking in magnitude and/or delayed significantly. Also that some of the biologically significant differences may be in different classes of antibody. We have also previously shown that normal young B-cell repertoires can vary between different phenotypic subsets of B ce"],"journal":["Philosophical transactions of the Royal Society of London. Series B, Biological sciences"],"pubmed_title":["Ageing of the B-cell repertoire."],"pmcid":["PMC4528414"],"funding_grant_id":["886421","MR/L01257X/1","BB/G017190/1"],"pubmed_authors":["Martin V","Kipling D","Dunn-Walters D","Bryan Wu YC"],"additional_accession":[]},"is_claimable":false,"name":"Ageing of the B-cell repertoire.","description":"Older people are more susceptible to infection, less responsive to vaccination and have a more inflammatory immune environment. Using spectratype analysis, we have previously shown that the B-cell repertoire of older people shows evidence of inappropriate clonal expansions in the absence of challenge, and that this loss of B-cell diversity correlates with poor health. Studies on response to vaccination, using both spectratyping and high-throughput sequencing of the repertoire, indicate that older responses to challenge are lacking in magnitude and/or delayed significantly. Also that some of the biologically significant differences may be in different classes of antibody. We have also previously shown that normal young B-cell repertoires can vary between different phenotypic subsets of B ce","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Sep","modification":"2025-04-04T21:25:28.796Z","creation":"2019-03-26T22:39:15Z"},"accession":"S-EPMC4528414","cross_references":{"pubmed":["26194751"],"doi":["10.1098/rstb.2014.0237"]}}